MATHEMATICAL MODELING OF THE RETENTION AND CLEARANCE OF LOW-TOXICITY PARTICLES IN THE LUNG

A mathematical model has been formulated to describe the mechanisms that determine the retention or clearance of insoluble inhaled particles in the rat lung. The hypotheses underlying the model are described - for example, the phagocytosis of free particles by macrophages, the transport of particles...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Inhalation toxicology 1999-12, Vol.11 (12), p.1059-1076
Hauptverfasser:	Tran, C L, Jones, A D, Cullen, R T, Donaldson, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Cell Death Inhalation Exposure - adverse effects Inhalation Exposure - statistics & numerical data Lung - metabolism Lung - pathology Macrophages - drug effects Models, Biological Models, Theoretical Mucociliary Clearance Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!