Environmental Semen studies-is Infertility Increased by a Decline in Sperm Count?
The objective of the studies was to evaluate infertility according to sperm count shifts. The distribution of the sperm count of 1024 Danish men (median 56 million/ml) served as reference. The data were transformed with multiplicative or additive models to create alternative distributions with media...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1999-01, Vol.25 (1), p.12-16 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Bonde, Jens Peter E Hjollund, Niels Hl Kolstad, Henrik A Abell, Annette Larsen, Solveig B |
| description | The objective of the studies was to evaluate infertility according to sperm count shifts. The distribution of the sperm count of 1024 Danish men (median 56 million/ml) served as reference. The data were transformed with multiplicative or additive models to create alternative distributions with median sperm count values changed by 25—100%. Sperm-count-specific fecundabilities were provided from a follow-up of first-pregnancy planners in a Danish population. The estimated average fecundability of the 1024 Danish men was 16.9% [95% confidence interval (95% CI) 16.7—17.2], and the proportion of cohabiting men with spouses pregnant within 1 year was 86.0% (95% CI 84.1—87.8). Simulations of alternative sperm count distributions indicated that the relationship between sperm count shift and fertility strongly depends on the median level of the sperm count at onset and the type of shift, a dramatic decline from a high level in a multiplicative model indicating a marginal change and a minor decline from a low level in an additive model representing a strong decrease in fertility. In some cases sperm count, therefore, may be an early warning of changes in fertility. |
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The distribution of the sperm count of 1024 Danish men (median 56 million/ml) served as reference. The data were transformed with multiplicative or additive models to create alternative distributions with median sperm count values changed by 25—100%. Sperm-count-specific fecundabilities were provided from a follow-up of first-pregnancy planners in a Danish population. The estimated average fecundability of the 1024 Danish men was 16.9% [95% confidence interval (95% CI) 16.7—17.2], and the proportion of cohabiting men with spouses pregnant within 1 year was 86.0% (95% CI 84.1—87.8). Simulations of alternative sperm count distributions indicated that the relationship between sperm count shift and fertility strongly depends on the median level of the sperm count at onset and the type of shift, a dramatic decline from a high level in a multiplicative model indicating a marginal change and a minor decline from a low level in an additive model representing a strong decrease in fertility. In some cases sperm count, therefore, may be an early warning of changes in fertility.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>PMID: 10235399</identifier><language>eng</language><publisher>Finland: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Adult ; Censuses ; Denmark - epidemiology ; Fecundity ; Female ; Fertility ; Fertility rates ; Humans ; Male ; Middle Aged ; Modeling ; Models, Biological ; Occupational Exposure - statistics & numerical data ; Paternal Exposure - statistics & numerical data ; Pregnancy - statistics & numerical data ; Semen ; Semen analysis ; Simulations ; Sperm Count ; Spermatozoa ; Statistical median</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1999-01, Vol.25 (1), p.12-16</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40966966$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40966966$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10235399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonde, Jens Peter E</creatorcontrib><creatorcontrib>Hjollund, Niels Hl</creatorcontrib><creatorcontrib>Kolstad, Henrik A</creatorcontrib><creatorcontrib>Abell, Annette</creatorcontrib><creatorcontrib>Larsen, Solveig B</creatorcontrib><title>Environmental Semen studies-is Infertility Increased by a Decline in Sperm Count?</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>The objective of the studies was to evaluate infertility according to sperm count shifts. The distribution of the sperm count of 1024 Danish men (median 56 million/ml) served as reference. The data were transformed with multiplicative or additive models to create alternative distributions with median sperm count values changed by 25—100%. Sperm-count-specific fecundabilities were provided from a follow-up of first-pregnancy planners in a Danish population. The estimated average fecundability of the 1024 Danish men was 16.9% [95% confidence interval (95% CI) 16.7—17.2], and the proportion of cohabiting men with spouses pregnant within 1 year was 86.0% (95% CI 84.1—87.8). Simulations of alternative sperm count distributions indicated that the relationship between sperm count shift and fertility strongly depends on the median level of the sperm count at onset and the type of shift, a dramatic decline from a high level in a multiplicative model indicating a marginal change and a minor decline from a low level in an additive model representing a strong decrease in fertility. In some cases sperm count, therefore, may be an early warning of changes in fertility.</description><subject>Adult</subject><subject>Censuses</subject><subject>Denmark - epidemiology</subject><subject>Fecundity</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertility rates</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Modeling</subject><subject>Models, Biological</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Paternal Exposure - statistics & numerical data</subject><subject>Pregnancy - statistics & numerical data</subject><subject>Semen</subject><subject>Semen analysis</subject><subject>Simulations</subject><subject>Sperm Count</subject><subject>Spermatozoa</subject><subject>Statistical median</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFFLwzAUhYMobk5_gpIn3wo3SdMtTyJz08FAZAq-haa9hYw2nUkq7N-bsSkIF-65nI8L55yRMZsqmSkFn-dkDELKTLAcRuQqhC0AV5JPL8mIARdSKDUmbwv3bX3vOnSxbOkGk6AhDrXFkNlAV65BH21r4z7pymMZsKZmT0v6hFVrHVLr6GaHvqPzfnDx4ZpcNGUb8Oa0J-RjuXifv2Tr1-fV_HGdlYKLmOU5GNU0pkAGUtZmasSs4RVjvJk1Ip-BqVSDjINIWJ2CKDmtDUJtJNQcUEzI_fHvzvdfA4aoOxsqbNvSYT8EzXIJUnGZwLsTOJgOa73ztiv9Xv-WkIDbI7ANsfd_fg6qKNIkf3n0S-tttHrbD96laPrQ76FezZRSjGsODBhjkIou_h_JZIX4AYHkdhk</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Bonde, Jens Peter E</creator><creator>Hjollund, Niels Hl</creator><creator>Kolstad, Henrik A</creator><creator>Abell, Annette</creator><creator>Larsen, Solveig B</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute for Working Life</general><general>Finnish Institute of Occupational Health</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>19990101</creationdate><title>Environmental Semen studies-is Infertility Increased by a Decline in Sperm Count?</title><author>Bonde, Jens Peter E ; Hjollund, Niels Hl ; Kolstad, Henrik A ; Abell, Annette ; Larsen, Solveig B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a323t-440b9ffb6e1055db7b38f2c112f8f3480bc9fe1203b9fd355957dbe0db50d20e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Censuses</topic><topic>Denmark - epidemiology</topic><topic>Fecundity</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility rates</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Modeling</topic><topic>Models, Biological</topic><topic>Occupational Exposure - statistics & numerical data</topic><topic>Paternal Exposure - statistics & numerical data</topic><topic>Pregnancy - statistics & numerical data</topic><topic>Semen</topic><topic>Semen analysis</topic><topic>Simulations</topic><topic>Sperm Count</topic><topic>Spermatozoa</topic><topic>Statistical median</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonde, Jens Peter E</creatorcontrib><creatorcontrib>Hjollund, Niels Hl</creatorcontrib><creatorcontrib>Kolstad, Henrik A</creatorcontrib><creatorcontrib>Abell, Annette</creatorcontrib><creatorcontrib>Larsen, Solveig B</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonde, Jens Peter E</au><au>Hjollund, Niels Hl</au><au>Kolstad, Henrik A</au><au>Abell, Annette</au><au>Larsen, Solveig B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental Semen studies-is Infertility Increased by a Decline in Sperm Count?</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>25</volume><issue>1</issue><spage>12</spage><epage>16</epage><pages>12-16</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>The objective of the studies was to evaluate infertility according to sperm count shifts. The distribution of the sperm count of 1024 Danish men (median 56 million/ml) served as reference. The data were transformed with multiplicative or additive models to create alternative distributions with median sperm count values changed by 25—100%. Sperm-count-specific fecundabilities were provided from a follow-up of first-pregnancy planners in a Danish population. The estimated average fecundability of the 1024 Danish men was 16.9% [95% confidence interval (95% CI) 16.7—17.2], and the proportion of cohabiting men with spouses pregnant within 1 year was 86.0% (95% CI 84.1—87.8). Simulations of alternative sperm count distributions indicated that the relationship between sperm count shift and fertility strongly depends on the median level of the sperm count at onset and the type of shift, a dramatic decline from a high level in a multiplicative model indicating a marginal change and a minor decline from a low level in an additive model representing a strong decrease in fertility. In some cases sperm count, therefore, may be an early warning of changes in fertility.</abstract><cop>Finland</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>10235399</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Censuses Denmark - epidemiology Fecundity Female Fertility Fertility rates Humans Male Middle Aged Modeling Models, Biological Occupational Exposure - statistics & numerical data Paternal Exposure - statistics & numerical data Pregnancy - statistics & numerical data Semen Semen analysis Simulations Sperm Count Spermatozoa Statistical median |
| title | Environmental Semen studies-is Infertility Increased by a Decline in Sperm Count? |
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