Effects of pyperonyl butoxide on the female reproductive tract in rats

This study was investigated the effects of piperonyl butoxide (PBO) on the female reproductive tract. Female Crj:Donryu rats were fed a basal diet containing 5,000, 10,000 or 20,000 ppm PBO for 28 days, and compared with food-restricted rats of comparable body weights to those in the PBO 10,000 or 2...

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Veröffentlicht in:	Journal of toxicological sciences 2013/12/01, Vol.38(6), pp.891-902
Hauptverfasser:	Hayashi, Seigo, Taketa, Yoshikazu, Inoue, Kaoru, Takahashi, Miwa, Matsuo, Saori, Irie, Kaoru, Watanabe, Gen, Yoshida, Midori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-uterotrophic assay Body Weight - drug effects Dose-Response Relationship, Drug Estradiol - blood Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - genetics Estrous Cycle - drug effects Female Female reproductive tract Genes, Reporter Genetic Techniques Hypertrophy Organ Size - drug effects Ovary - drug effects Pesticide Synergists - adverse effects Piperonyl butoxide Piperonyl Butoxide - adverse effects Rats Rats, Inbred Strains Reporter gene assay Uterus - drug effects Uterus - pathology Weight Gain - drug effects
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