Evaluation of an affordable HIV-1 virological failure assay and antiretroviral drug resistance genotyping protocol

•A virological failure (VF) and HIV drug resistance (HIVDR) assay was evaluated.•248 subtype C samples from patients failing first line therapy were tested.•VF assay performed well on both plasma and DBS, measured against a reference assay.•HIVDR assay showed reliable amplification and sequencing re...

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Veröffentlicht in:	Journal of virological methods 2013-12, Vol.194 (1-2), p.300-307
Hauptverfasser:	Bronze, M., Aitken, S.C., Wallis, C.L., Steegen, K., Stuyver, L.J., de Wit, T.F. Rinke, Stevens, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use antiretroviral agents Antiretroviral drug resistance blood drug resistance Drug Resistance, Viral genes Genotyping HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - isolation & purification HIV-1 virological failure assay Human immunodeficiency virus 1 Humans Microbial Sensitivity Tests - methods Molecular Diagnostic Techniques - methods monitoring mutation RNA RNA-directed DNA polymerase Sensitivity and Specificity South Africa therapeutics Treatment Failure viral load Viral Load - methods
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