The complexity of DNA double strand breaks is a critical factor enhancing end-resection

•Heavy ion beam-induced complex DSBs efficiently activate DNA end resection.•Up to 85% of complex DSBs undergo resection in G2 cells.•Around 20–40% of human G1 cells exhibit resection signals.•ATM kinase activity promotes but is not essential for end resection. DNA double strand breaks (DSBs) induce...

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Veröffentlicht in:	DNA repair 2013-11, Vol.12 (11), p.936-946
Hauptverfasser:	Yajima, Hirohiko, Fujisawa, Hiroshi, Nakajima, Nakako Izumi, Hirakawa, Hirokazu, Jeggo, Penelope A., Okayasu, Ryuichi, Fujimori, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Telangiectasia Mutated Proteins - metabolism ATM Carrier Proteins - metabolism Cell Cycle - drug effects Cell Cycle - genetics Cell Cycle - radiation effects Cell Line complex DNA damage structure CtIP DNA Breaks, Double-Stranded DNA double strand breaks DNA end resection DNA End-Joining Repair - genetics DNA, Single-Stranded - metabolism Endodeoxyribonucleases HeLa Cells Heterochromatin - genetics Heterochromatin - metabolism homologous recombination Humans Linear Energy Transfer Mice Morpholines - pharmacology Nuclear Proteins - metabolism Phosphorylation Pyrones - pharmacology Radiation, Ionizing Recombinational DNA Repair Replication Protein A - metabolism
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