Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats
The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously int...
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| Veröffentlicht in: | European journal of pharmacology 2013-10, Vol.718 (1-3), p.213-218 |
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| creator | Queenthy, S.Sharmila John, Babu |
| description | The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase. The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin. |
| doi_str_mv | 10.1016/j.ejphar.2013.08.031 |
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Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase. The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2013.08.031</identifier><identifier>PMID: 24036254</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biomarkers - blood ; blood lipids ; blood serum ; body weight ; cardioprotective effect ; Diosmin ; Diosmin - pharmacology ; Electrocardiogram ; electrocardiography ; enzymes ; free radical scavengers ; Heart Ventricles - drug effects ; Heart Ventricles - pathology ; Hypolipidemic Agents - pharmacology ; in vitro studies ; Isoproterenol ; Isoproterenol - adverse effects ; lipid metabolism ; Lipid Metabolism - drug effects ; lipid peroxidation ; Lipids ; Lipo proteins ; liver ; Male ; Myocardial infarction ; Myocardial Infarction - chemically induced ; Myocardial Infarction - metabolism ; Myocardial Infarction - pathology ; oral administration ; Rats ; Rats, Wistar</subject><ispartof>European journal of pharmacology, 2013-10, Vol.718 (1-3), p.213-218</ispartof><rights>2013 Elsevier B.V.</rights><rights>2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1a321fd82cf7e94ecf3f8faa805375fc3f83e57d41071874c5528f24bbd9a01b3</citedby><cites>FETCH-LOGICAL-c386t-1a321fd82cf7e94ecf3f8faa805375fc3f83e57d41071874c5528f24bbd9a01b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2013.08.031$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24036254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Queenthy, S.Sharmila</creatorcontrib><creatorcontrib>John, Babu</creatorcontrib><title>Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase. The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin.</description><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>blood lipids</subject><subject>blood serum</subject><subject>body weight</subject><subject>cardioprotective effect</subject><subject>Diosmin</subject><subject>Diosmin - pharmacology</subject><subject>Electrocardiogram</subject><subject>electrocardiography</subject><subject>enzymes</subject><subject>free radical scavengers</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - pathology</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>in vitro studies</subject><subject>Isoproterenol</subject><subject>Isoproterenol - adverse effects</subject><subject>lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>lipid peroxidation</subject><subject>Lipids</subject><subject>Lipo proteins</subject><subject>liver</subject><subject>Male</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - chemically induced</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - pathology</subject><subject>oral administration</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAURi1ERYfCP0Awy24SfP1InA0S6gOQKrGAri3HvmY8SuLUzlSdf49HaVmysvz53IcPIR-A1kCh-byvcT_vTKoZBV5TVVMOr8gGVNtVtAX2mmwoBVGxruvOyduc95RS2TH5hpwzQXnDpNgQfR1iHsO0xadd6MOSt2ZaQrU7zpiGMAeHY7Bb9B5teStcyHFOccGEUxxK4A4W3XY8RmuSC-YUeZPsUsJklvyOnHkzZHz_fF6Q-9ub31ffq7uf335cfb2rLFfNUoHhDLxTzPoWO4HWc6-8MYpK3kpvy42jbJ2A8jXVCislU56JvnedodDzC3K59i3LPRwwL3oM2eIwmAnjIWsQkkKrJPCCihW1Keac0Os5hdGkowaqT2r1Xq9q9UmtpkoXtaXs4_OEQz-i-1f04rIAn1bAm6jNnxSyvv9VOsjiXUDTyEJ8WQksJh4DJp1twKkIDKn41S6G_-_wF3Exlx8</recordid><startdate>20131015</startdate><enddate>20131015</enddate><creator>Queenthy, S.Sharmila</creator><creator>John, Babu</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131015</creationdate><title>Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats</title><author>Queenthy, S.Sharmila ; John, Babu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1a321fd82cf7e94ecf3f8faa805375fc3f83e57d41071874c5528f24bbd9a01b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>blood lipids</topic><topic>blood serum</topic><topic>body weight</topic><topic>cardioprotective effect</topic><topic>Diosmin</topic><topic>Diosmin - pharmacology</topic><topic>Electrocardiogram</topic><topic>electrocardiography</topic><topic>enzymes</topic><topic>free radical scavengers</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - pathology</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>in vitro studies</topic><topic>Isoproterenol</topic><topic>Isoproterenol - adverse effects</topic><topic>lipid metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>lipid peroxidation</topic><topic>Lipids</topic><topic>Lipo proteins</topic><topic>liver</topic><topic>Male</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - chemically induced</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - pathology</topic><topic>oral administration</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Queenthy, S.Sharmila</creatorcontrib><creatorcontrib>John, Babu</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Queenthy, S.Sharmila</au><au>John, Babu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2013-10-15</date><risdate>2013</risdate><volume>718</volume><issue>1-3</issue><spage>213</spage><epage>218</epage><pages>213-218</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase. The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24036254</pmid><doi>10.1016/j.ejphar.2013.08.031</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biomarkers - blood blood lipids blood serum body weight cardioprotective effect Diosmin Diosmin - pharmacology Electrocardiogram electrocardiography enzymes free radical scavengers Heart Ventricles - drug effects Heart Ventricles - pathology Hypolipidemic Agents - pharmacology in vitro studies Isoproterenol Isoproterenol - adverse effects lipid metabolism Lipid Metabolism - drug effects lipid peroxidation Lipids Lipo proteins liver Male Myocardial infarction Myocardial Infarction - chemically induced Myocardial Infarction - metabolism Myocardial Infarction - pathology oral administration Rats Rats, Wistar |
| title | Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats |
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