Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH

Trisomies 18 and 21 are genetic disorders in which cells possess an extra copy of each of the relevant chromosomes. Individuals with these disorders who survive birth generally have a shortened life expectancy. As telomeres are known to play an important role in the maintenance of genomic integrity...

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Veröffentlicht in:	Gene 2014-01, Vol.533 (1), p.199-207
Hauptverfasser:	Nakamura, Ken-ichi, Ishikawa, Naoshi, Izumiyama, Naotaka, Aida, Junko, Kuroiwa, Mie, Hiraishi, Naoki, Fujiwara, Mutsunori, Nakao, Atsushi, Kawakami, Tadashi, Poon, Steven S.S., Matsuura, Masaaki, Sawabe, Motoji, Arai, Tomio, Takubo, Kaiyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Chromosomes, Human, Pair 18 Diploidy Down syndrome Down Syndrome - genetics Humans In Situ Hybridization, Fluorescence - methods Infant, Newborn Karyotyping Q-FISH Telomere Trisomy Trisomy 18 Trisomy 21
Online-Zugang:	Volltext
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