Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)

The efficacy of DTPA treatment for intramuscularly administered Np(IV) citrate and Np(V) in 0.1 M HNO3 was investigated in rats. Chelation treatment was performed near the site of the Np injection, at different post-injection times. For wounds contaminated with Np(IV) citrate, significant Np decorpo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Radiation protection dosimetry 1998-01, Vol.79 (1-4), p.463-465
Hauptverfasser:	Ramounet, B., Matton, S., Grillon, G., Poncy, J.L., Fritsch, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological effects of radiation Fundamental and applied biological sciences. Psychology Radiocontamination Tissues, organs and organisms biophysics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	465
container_issue	1-4
container_start_page	463
container_title	Radiation protection dosimetry
container_volume	79
creator	Ramounet, B. Matton, S. Grillon, G. Poncy, J.L. Fritsch, P.
description	The efficacy of DTPA treatment for intramuscularly administered Np(IV) citrate and Np(V) in 0.1 M HNO3 was investigated in rats. Chelation treatment was performed near the site of the Np injection, at different post-injection times. For wounds contaminated with Np(IV) citrate, significant Np decorporation was obtained when treatment was performed at 2 min. Treatment efficacy gradually decreased with treatment delay and no decorporation was observed if treatment was delayed by 1 h. All other treatments were performed 20 min after the i.m. Np injection. Similar decorporation, 20 to 30% of administered Np(IV), was observed over range of Np mass from 10-4 to 10µg, but no decorporation of Np(V) was observed. Taking account of the biokinetics of Np(IV) and Np(V), it seems that most of the present results can be explained by the kinetics of Np deposition in the skeleton, which depends on the Np valence.
doi_str_mv	10.1093/oxfordjournals.rpd.a032450
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_14501067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>14501067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-ec27e462dcf0a1d31005d6a9876d5cd885dd686cd36281a35865dc5cc36b25783</originalsourceid><addsrcrecordid>eNpVkF1r2zAUhsVYYVna_yBKKeuFM8myZGV3Xdu0gfSDNiujN-L0SKbOHMuTbGj-_RQSNnYlwXnOeV8eQo45m3A2FV_9e-WDXfkhtNDESejsBJjIC8k-kBEvizwTBVMfyYjxosh0kbNP5HOMK8byciqLEXm7qqoaATfUV3ThEZo6Oksvlw_ndBkc9GvX9jSF0EuHPnQ-QF_7dkvfdXTerhz2iZ-3fYD1EHFoIDQbCjGNv8yfz2jaTL_ns0NyUKWK7mj_jsmP2dXy4iZb3F_PL84XGQo57TOHeekKlVusGHArOGPSKpjqUlmJVmtprdIKrVC55iCkVtKiRBTqNZelFmNyurvbBf97cLE36zqiaxponR-i4ckNZ6pM4LcdiMHHGFxlulCvIWwMZ2Yr1_wv1yS5Zi83LZ_sUyAmZ1WAFuv474LUqdc2I9thdezd-98xhF8mNSilufn5Yp4W32-vH8qZeRR_APs-j7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14501067</pqid></control><display><type>article</type><title>Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)</title><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Ramounet, B. ; Matton, S. ; Grillon, G. ; Poncy, J.L. ; Fritsch, P.</creator><creatorcontrib>Ramounet, B. ; Matton, S. ; Grillon, G. ; Poncy, J.L. ; Fritsch, P.</creatorcontrib><description>The efficacy of DTPA treatment for intramuscularly administered Np(IV) citrate and Np(V) in 0.1 M HNO3 was investigated in rats. Chelation treatment was performed near the site of the Np injection, at different post-injection times. For wounds contaminated with Np(IV) citrate, significant Np decorporation was obtained when treatment was performed at 2 min. Treatment efficacy gradually decreased with treatment delay and no decorporation was observed if treatment was delayed by 1 h. All other treatments were performed 20 min after the i.m. Np injection. Similar decorporation, 20 to 30% of administered Np(IV), was observed over range of Np mass from 10-4 to 10µg, but no decorporation of Np(V) was observed. Taking account of the biokinetics of Np(IV) and Np(V), it seems that most of the present results can be explained by the kinetics of Np deposition in the skeleton, which depends on the Np valence.</description><identifier>ISSN: 0144-8420</identifier><identifier>EISSN: 1742-3406</identifier><identifier>DOI: 10.1093/oxfordjournals.rpd.a032450</identifier><identifier>CODEN: RPDODE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Biological effects of radiation ; Fundamental and applied biological sciences. Psychology ; Radiocontamination ; Tissues, organs and organisms biophysics</subject><ispartof>Radiation protection dosimetry, 1998-01, Vol.79 (1-4), p.463-465</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-ec27e462dcf0a1d31005d6a9876d5cd885dd686cd36281a35865dc5cc36b25783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,782,786,791,792,23937,23938,25147,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1588657$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramounet, B.</creatorcontrib><creatorcontrib>Matton, S.</creatorcontrib><creatorcontrib>Grillon, G.</creatorcontrib><creatorcontrib>Poncy, J.L.</creatorcontrib><creatorcontrib>Fritsch, P.</creatorcontrib><title>Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)</title><title>Radiation protection dosimetry</title><addtitle>Radiat Prot Dosimetry</addtitle><description>The efficacy of DTPA treatment for intramuscularly administered Np(IV) citrate and Np(V) in 0.1 M HNO3 was investigated in rats. Chelation treatment was performed near the site of the Np injection, at different post-injection times. For wounds contaminated with Np(IV) citrate, significant Np decorporation was obtained when treatment was performed at 2 min. Treatment efficacy gradually decreased with treatment delay and no decorporation was observed if treatment was delayed by 1 h. All other treatments were performed 20 min after the i.m. Np injection. Similar decorporation, 20 to 30% of administered Np(IV), was observed over range of Np mass from 10-4 to 10µg, but no decorporation of Np(V) was observed. Taking account of the biokinetics of Np(IV) and Np(V), it seems that most of the present results can be explained by the kinetics of Np deposition in the skeleton, which depends on the Np valence.</description><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Radiocontamination</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0144-8420</issn><issn>1742-3406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpVkF1r2zAUhsVYYVna_yBKKeuFM8myZGV3Xdu0gfSDNiujN-L0SKbOHMuTbGj-_RQSNnYlwXnOeV8eQo45m3A2FV_9e-WDXfkhtNDESejsBJjIC8k-kBEvizwTBVMfyYjxosh0kbNP5HOMK8byciqLEXm7qqoaATfUV3ThEZo6Oksvlw_ndBkc9GvX9jSF0EuHPnQ-QF_7dkvfdXTerhz2iZ-3fYD1EHFoIDQbCjGNv8yfz2jaTL_ns0NyUKWK7mj_jsmP2dXy4iZb3F_PL84XGQo57TOHeekKlVusGHArOGPSKpjqUlmJVmtprdIKrVC55iCkVtKiRBTqNZelFmNyurvbBf97cLE36zqiaxponR-i4ckNZ6pM4LcdiMHHGFxlulCvIWwMZ2Yr1_wv1yS5Zi83LZ_sUyAmZ1WAFuv474LUqdc2I9thdezd-98xhF8mNSilufn5Yp4W32-vH8qZeRR_APs-j7A</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Ramounet, B.</creator><creator>Matton, S.</creator><creator>Grillon, G.</creator><creator>Poncy, J.L.</creator><creator>Fritsch, P.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>19980101</creationdate><title>Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)</title><author>Ramounet, B. ; Matton, S. ; Grillon, G. ; Poncy, J.L. ; Fritsch, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-ec27e462dcf0a1d31005d6a9876d5cd885dd686cd36281a35865dc5cc36b25783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Radiocontamination</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramounet, B.</creatorcontrib><creatorcontrib>Matton, S.</creatorcontrib><creatorcontrib>Grillon, G.</creatorcontrib><creatorcontrib>Poncy, J.L.</creatorcontrib><creatorcontrib>Fritsch, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Radiation protection dosimetry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramounet, B.</au><au>Matton, S.</au><au>Grillon, G.</au><au>Poncy, J.L.</au><au>Fritsch, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)</atitle><jtitle>Radiation protection dosimetry</jtitle><addtitle>Radiat Prot Dosimetry</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>79</volume><issue>1-4</issue><spage>463</spage><epage>465</epage><pages>463-465</pages><issn>0144-8420</issn><eissn>1742-3406</eissn><coden>RPDODE</coden><abstract>The efficacy of DTPA treatment for intramuscularly administered Np(IV) citrate and Np(V) in 0.1 M HNO3 was investigated in rats. Chelation treatment was performed near the site of the Np injection, at different post-injection times. For wounds contaminated with Np(IV) citrate, significant Np decorporation was obtained when treatment was performed at 2 min. Treatment efficacy gradually decreased with treatment delay and no decorporation was observed if treatment was delayed by 1 h. All other treatments were performed 20 min after the i.m. Np injection. Similar decorporation, 20 to 30% of administered Np(IV), was observed over range of Np mass from 10-4 to 10µg, but no decorporation of Np(V) was observed. Taking account of the biokinetics of Np(IV) and Np(V), it seems that most of the present results can be explained by the kinetics of Np deposition in the skeleton, which depends on the Np valence.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><doi>10.1093/oxfordjournals.rpd.a032450</doi><tpages>3</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0144-8420
ispartof	Radiation protection dosimetry, 1998-01, Vol.79 (1-4), p.463-465
issn	0144-8420 1742-3406
language	eng
recordid	cdi_proquest_miscellaneous_14501067
source	Oxford University Press Journals All Titles (1996-Current)
subjects	Biological and medical sciences Biological effects of radiation Fundamental and applied biological sciences. Psychology Radiocontamination Tissues, organs and organisms biophysics
title	Efficacy of Localised DTPA Treatment for Decorporation of Np Injected Intramuscularly as Np(IV) or Np(V)
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T18%3A01%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20Localised%20DTPA%20Treatment%20for%20Decorporation%20of%20Np%20Injected%20Intramuscularly%20as%20Np(IV)%20or%20Np(V)&rft.jtitle=Radiation%20protection%20dosimetry&rft.au=Ramounet,%20B.&rft.date=1998-01-01&rft.volume=79&rft.issue=1-4&rft.spage=463&rft.epage=465&rft.pages=463-465&rft.issn=0144-8420&rft.eissn=1742-3406&rft.coden=RPDODE&rft_id=info:doi/10.1093/oxfordjournals.rpd.a032450&rft_dat=%3Cproquest_cross%3E14501067%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14501067&rft_id=info:pmid/&rfr_iscdi=true