Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting
Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The ai...
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| Veröffentlicht in: | Inflammation 2013-12, Vol.36 (6), p.1327-1333 |
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| creator | Baki, Elif Doğan Aldemir, Mustafa Kokulu, Serdar Koca, Halit Buğra Ela, Yüksel Sıvacı, Remziye Gül Öztürk, Nilgün Kavrut Emmiler, Mustafa Adalı, Fahri Uzel, Hanife |
| description | Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (
n
= 20) or desflurane (
n
= 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG. |
| doi_str_mv | 10.1007/s10753-013-9671-6 |
| format | Article |
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n
= 20) or desflurane (
n
= 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/s10753-013-9671-6</identifier><identifier>PMID: 23775574</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Anesthesia - methods ; Anesthetics, Inhalation - therapeutic use ; Anesthetics, Intravenous - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Cardiotonic Agents - therapeutic use ; Central Nervous System - drug effects ; Coronary Artery Bypass - adverse effects ; Desflurane ; Female ; Humans ; Immunology ; Inflammation - drug therapy ; Inflammation - immunology ; Interleukin-6 - blood ; Interleukin-8 - blood ; Internal Medicine ; Isoflurane - analogs & derivatives ; Isoflurane - therapeutic use ; Male ; Middle Aged ; Pathology ; Pharmacology/Toxicology ; Propofol - therapeutic use ; Prospective Studies ; Rheumatology ; S100 Calcium Binding Protein beta Subunit - blood ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Inflammation, 2013-12, Vol.36 (6), p.1327-1333</ispartof><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-8cdfc3b7ec23f0e2a248e2b2fb1b2224db9971ebe07049bed32436438993e4ed3</citedby><cites>FETCH-LOGICAL-c344t-8cdfc3b7ec23f0e2a248e2b2fb1b2224db9971ebe07049bed32436438993e4ed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10753-013-9671-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10753-013-9671-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23775574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baki, Elif Doğan</creatorcontrib><creatorcontrib>Aldemir, Mustafa</creatorcontrib><creatorcontrib>Kokulu, Serdar</creatorcontrib><creatorcontrib>Koca, Halit Buğra</creatorcontrib><creatorcontrib>Ela, Yüksel</creatorcontrib><creatorcontrib>Sıvacı, Remziye Gül</creatorcontrib><creatorcontrib>Öztürk, Nilgün Kavrut</creatorcontrib><creatorcontrib>Emmiler, Mustafa</creatorcontrib><creatorcontrib>Adalı, Fahri</creatorcontrib><creatorcontrib>Uzel, Hanife</creatorcontrib><title>Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting</title><title>Inflammation</title><addtitle>Inflammation</addtitle><addtitle>Inflammation</addtitle><description>Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (
n
= 20) or desflurane (
n
= 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia - methods</subject><subject>Anesthetics, Inhalation - therapeutic use</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Central Nervous System - drug effects</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Desflurane</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - immunology</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Internal Medicine</subject><subject>Isoflurane - analogs & derivatives</subject><subject>Isoflurane - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Pharmacology/Toxicology</subject><subject>Propofol - therapeutic use</subject><subject>Prospective Studies</subject><subject>Rheumatology</subject><subject>S100 Calcium Binding Protein beta Subunit - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1jAQhS0Eoj-FB-im8pJNwLfE8fLv3wuVKoG4rC0nGbepEjv1JIu-SB-EB-GZ6iiFJavRyOc78plDyAlnnzhj-jNypktZMC4LU2leVK_IjpdaFqLU1WuyY7JihTRGH5F3iPeMsdrU8i05ElLrstRqR54OcZxc6jEGGj2d74BeeA_tjOt6DuiHJbkA1IWOfktxij4OdB8AsxR7RzO3QtfBD24c3RzTI_0OOMWAG_Qjf_XP75WdoQ_0fEl9uKWHmGJwWbtPM-Rx9jg5RHqVnJ_z-3vyxrsB4cPLPCa_Li9-Hr4UN1-vrg_7m6KVSs1F3Xa-lY2GVkjPQDihahCN8A1vhBCqa3J4Dg0wzZRpoJNCyUrJ2hgJKq_H5OPmO6X4sORQduyxhWHIkeOClitldGVKKbKUb9I2RcQE3k6pH3MEy5ld67BbHTbXYdc6bJWZ0xf7pRmh-0f8vX8WiE2A03oWSPY-LinkyP9xfQaMDJg_</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Baki, Elif Doğan</creator><creator>Aldemir, Mustafa</creator><creator>Kokulu, Serdar</creator><creator>Koca, Halit Buğra</creator><creator>Ela, Yüksel</creator><creator>Sıvacı, Remziye Gül</creator><creator>Öztürk, Nilgün Kavrut</creator><creator>Emmiler, Mustafa</creator><creator>Adalı, Fahri</creator><creator>Uzel, Hanife</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting</title><author>Baki, Elif Doğan ; Aldemir, Mustafa ; Kokulu, Serdar ; Koca, Halit Buğra ; Ela, Yüksel ; Sıvacı, Remziye Gül ; Öztürk, Nilgün Kavrut ; Emmiler, Mustafa ; Adalı, Fahri ; Uzel, Hanife</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-8cdfc3b7ec23f0e2a248e2b2fb1b2224db9971ebe07049bed32436438993e4ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia - methods</topic><topic>Anesthetics, Inhalation - therapeutic use</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Central Nervous System - drug effects</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Desflurane</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation - immunology</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - blood</topic><topic>Internal Medicine</topic><topic>Isoflurane - analogs & derivatives</topic><topic>Isoflurane - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Pharmacology/Toxicology</topic><topic>Propofol - therapeutic use</topic><topic>Prospective Studies</topic><topic>Rheumatology</topic><topic>S100 Calcium Binding Protein beta Subunit - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baki, Elif Doğan</creatorcontrib><creatorcontrib>Aldemir, Mustafa</creatorcontrib><creatorcontrib>Kokulu, Serdar</creatorcontrib><creatorcontrib>Koca, Halit Buğra</creatorcontrib><creatorcontrib>Ela, Yüksel</creatorcontrib><creatorcontrib>Sıvacı, Remziye Gül</creatorcontrib><creatorcontrib>Öztürk, Nilgün Kavrut</creatorcontrib><creatorcontrib>Emmiler, Mustafa</creatorcontrib><creatorcontrib>Adalı, Fahri</creatorcontrib><creatorcontrib>Uzel, Hanife</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baki, Elif Doğan</au><au>Aldemir, Mustafa</au><au>Kokulu, Serdar</au><au>Koca, Halit Buğra</au><au>Ela, Yüksel</au><au>Sıvacı, Remziye Gül</au><au>Öztürk, Nilgün Kavrut</au><au>Emmiler, Mustafa</au><au>Adalı, Fahri</au><au>Uzel, Hanife</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting</atitle><jtitle>Inflammation</jtitle><stitle>Inflammation</stitle><addtitle>Inflammation</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>36</volume><issue>6</issue><spage>1327</spage><epage>1333</epage><pages>1327-1333</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><abstract>Cardiopulmonary bypass (CPB) contributes to the secretion of anti-inflammatory cytokines that mediate the inflammatory response observed during open heart surgery. In addition to many factors, type of anesthesia management affects immune response and central nervous system in cardiac surgery. The aim of this study was to assess the effect of propofol versus desflurane anesthesia on systemic immune modulation and central nervous system on patients undergoing coronary artery bypass grafting. Forty patients undergoing elective coronary artery bypass graft surgery with CPB were included in this prospective randomized study. Patients were allocated to receive propofol (
n
= 20) or desflurane (
n
= 20) for maintenance of anesthesia. The blood samples for IL-6, IL-8, TNF-α, and S100β were drawn just prior to the operation before the induction of anesthesia, second before cardiopulmonary bypass, third after CPB, fourth 4 h postoperatively at the ICU. Major finding in our study is that S100β levels were lower in propofol group when compared to desflurane anesthesia. And also immune reaction was less in patients exposed to desflurane anesthesia when compared to propofol anesthesia as indicated by lower plasma concentrations of IL-8 and IL-6. Propofol is more preferable in terms of S100β for anesthetic management for CABG.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23775574</pmid><doi>10.1007/s10753-013-9671-6</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Inflammation, 2013-12, Vol.36 (6), p.1327-1333 |
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| subjects | Adult Aged Anesthesia - methods Anesthetics, Inhalation - therapeutic use Anesthetics, Intravenous - therapeutic use Biomedical and Life Sciences Biomedicine Cardiotonic Agents - therapeutic use Central Nervous System - drug effects Coronary Artery Bypass - adverse effects Desflurane Female Humans Immunology Inflammation - drug therapy Inflammation - immunology Interleukin-6 - blood Interleukin-8 - blood Internal Medicine Isoflurane - analogs & derivatives Isoflurane - therapeutic use Male Middle Aged Pathology Pharmacology/Toxicology Propofol - therapeutic use Prospective Studies Rheumatology S100 Calcium Binding Protein beta Subunit - blood Tumor Necrosis Factor-alpha - blood |
| title | Comparison of the Effects of Desflurane and Propofol Anesthesia on the Inflammatory Response and S100β Protein During Coronary Artery Bypass Grafting |
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