Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo

Abstract Background aims Cancer is one of the greatest health challenges facing the world today with >10 million new cases of cancer every year. The self-renewal, tumor-homing ability and low immunogenicity of mesenchymal stromal cells (MSCs) make them potential delivery candidates for suicide ge...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2013-12, Vol.15 (12), p.1484-1497
Hauptverfasser:	Lee, Wayne Y.W, Zhang, Ting, Lau, Carol P.Y, Wang, C.C, Chan, Kai-Ming, Li, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Bone Marrow Cells - cytology Cell Line, Tumor Drug Delivery Systems fetal mesenchymal stromal cells Fetus - cytology ganciclovir Ganciclovir - administration & dosage Gene Expression Regulation - drug effects Genes, Transgenic, Suicide - genetics Genetic Therapy Humans Male Mesenchymal Stromal Cells - chemistry Mesenchymal Stromal Cells - cytology Mice Other prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Simian virus 40 thymidine kinase
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