The presence of PCDDs and PCDFs in human breast milk from the Netherlands
Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern. The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,...
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| Veröffentlicht in: | Chemosphere (Oxford) 1986, Vol.15 (6), p.693-706 |
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| creator | van den Berg, Martin van der Wielen, Frans W.M. Olie, Kees van Boxtel, Chris.J. |
| description | Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern.
The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2 – 5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3 – 19.1) and OCDD (1.7 – 37.8 ppt), with concentrations on total milk basis.
Minor components were 1,2,3,7,8-PnCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (⩽ 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for congeners having an equal number of chlorine atoms or those with a difference of one chlorine atom.
By using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months. |
| doi_str_mv | 10.1016/0045-6535(86)90035-4 |
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The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2 – 5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3 – 19.1) and OCDD (1.7 – 37.8 ppt), with concentrations on total milk basis.
Minor components were 1,2,3,7,8-PnCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (⩽ 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for congeners having an equal number of chlorine atoms or those with a difference of one chlorine atom.
By using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months.</description><identifier>ISSN: 0045-6535</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/0045-6535(86)90035-4</identifier><identifier>CODEN: CMSHAF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987) ; AGE GROUPS ; ANIMALS ; AROMATICS ; BENZOFURANS ; Biological and medical sciences ; BIOLOGICAL MATERIALS ; BODY ; BODY FLUIDS ; CHEMICAL ANALYSIS ; CHILDREN ; CHLORINATED AROMATIC HYDROCARBONS ; DIGESTIVE SYSTEM ; Environmental pollutants toxicology ; EUROPE ; FEMALES ; FOOD ; FURANS ; General aspects ; GLANDS ; HALOGENATED AROMATIC HYDROCARBONS ; HETEROCYCLIC COMPOUNDS ; INFANTS ; LACTATION ; LIVER ; MAMMALS ; MAN ; MATERIALS ; Medical sciences ; MILK ; NETHERLANDS ; ORGANIC CHLORINE COMPOUNDS ; ORGANIC COMPOUNDS ; ORGANIC HALOGEN COMPOUNDS ; ORGANIC OXYGEN COMPOUNDS ; ORGANS ; PRIMATES ; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT ; Toxicology ; UPTAKE ; VERTEBRATES ; WESTERN EUROPE ; WOMEN</subject><ispartof>Chemosphere (Oxford), 1986, Vol.15 (6), p.693-706</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-f37f4d6879ec3aa6ac3b231cbc30dba1f868279cf721c17cf90e6b71854a302e3</citedby><cites>FETCH-LOGICAL-c391t-f37f4d6879ec3aa6ac3b231cbc30dba1f868279cf721c17cf90e6b71854a302e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0045-6535(86)90035-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3548,4022,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7872859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5274971$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>van den Berg, Martin</creatorcontrib><creatorcontrib>van der Wielen, Frans W.M.</creatorcontrib><creatorcontrib>Olie, Kees</creatorcontrib><creatorcontrib>van Boxtel, Chris.J.</creatorcontrib><creatorcontrib>Univ. of Amsterdam, Netherlands</creatorcontrib><title>The presence of PCDDs and PCDFs in human breast milk from the Netherlands</title><title>Chemosphere (Oxford)</title><description>Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern.
The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2 – 5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3 – 19.1) and OCDD (1.7 – 37.8 ppt), with concentrations on total milk basis.
Minor components were 1,2,3,7,8-PnCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (⩽ 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for congeners having an equal number of chlorine atoms or those with a difference of one chlorine atom.
By using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months.</description><subject>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</subject><subject>AGE GROUPS</subject><subject>ANIMALS</subject><subject>AROMATICS</subject><subject>BENZOFURANS</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL MATERIALS</subject><subject>BODY</subject><subject>BODY FLUIDS</subject><subject>CHEMICAL ANALYSIS</subject><subject>CHILDREN</subject><subject>CHLORINATED AROMATIC HYDROCARBONS</subject><subject>DIGESTIVE SYSTEM</subject><subject>Environmental pollutants toxicology</subject><subject>EUROPE</subject><subject>FEMALES</subject><subject>FOOD</subject><subject>FURANS</subject><subject>General aspects</subject><subject>GLANDS</subject><subject>HALOGENATED AROMATIC HYDROCARBONS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>INFANTS</subject><subject>LACTATION</subject><subject>LIVER</subject><subject>MAMMALS</subject><subject>MAN</subject><subject>MATERIALS</subject><subject>Medical sciences</subject><subject>MILK</subject><subject>NETHERLANDS</subject><subject>ORGANIC CHLORINE COMPOUNDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC HALOGEN COMPOUNDS</subject><subject>ORGANIC OXYGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>PRIMATES</subject><subject>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</subject><subject>Toxicology</subject><subject>UPTAKE</subject><subject>VERTEBRATES</subject><subject>WESTERN EUROPE</subject><subject>WOMEN</subject><issn>0045-6535</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rFTEUhoMoeK39B10EKaKL0XxOko0gt1YLxXbRrkMmc8KNnY9rzlyh_96Mt3Tp5uQsnvfk5SHkjLNPnPH2M2NKN62W-oNtPzrGpG7UC7Lh1riGC2dfks0z8pq8QfzFWM1ptyFXdzug-wIIUwQ6J3q7vbhAGqZ-3S6R5onuDmOYaFcg4ELHPDzQVOaRLjX5E-osQ8XxLXmVwoBw-vSekPvLb3fbH831zfer7dfrJkrHlyZJk1Tf1moQZQhtiLITkscuStZ3gSfbWmFcTEbwyE1MjkHbGW61CpIJkCfk3fHujEv2GPMCcRfnaYK4eC2McoZX6P0R2pf59wFw8WPGCENtCvMBPVfKacFEBdURjGVGLJD8vuQxlEfPmV_l-tWcX8152_p_cr2qsfOn-wFjGFIJU8z4nDXWCKtdxb4cMahC_mQoa9_VdJ_LWref8___-QuYG4s8</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>van den Berg, Martin</creator><creator>van der Wielen, Frans W.M.</creator><creator>Olie, Kees</creator><creator>van Boxtel, Chris.J.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>OTOTI</scope></search><sort><creationdate>1986</creationdate><title>The presence of PCDDs and PCDFs in human breast milk from the Netherlands</title><author>van den Berg, Martin ; van der Wielen, Frans W.M. ; Olie, Kees ; van Boxtel, Chris.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-f37f4d6879ec3aa6ac3b231cbc30dba1f868279cf721c17cf90e6b71854a302e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>560306 - Chemicals Metabolism & Toxicology- Man- (-1987)</topic><topic>AGE GROUPS</topic><topic>ANIMALS</topic><topic>AROMATICS</topic><topic>BENZOFURANS</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL MATERIALS</topic><topic>BODY</topic><topic>BODY FLUIDS</topic><topic>CHEMICAL ANALYSIS</topic><topic>CHILDREN</topic><topic>CHLORINATED AROMATIC HYDROCARBONS</topic><topic>DIGESTIVE SYSTEM</topic><topic>Environmental pollutants toxicology</topic><topic>EUROPE</topic><topic>FEMALES</topic><topic>FOOD</topic><topic>FURANS</topic><topic>General aspects</topic><topic>GLANDS</topic><topic>HALOGENATED AROMATIC HYDROCARBONS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>INFANTS</topic><topic>LACTATION</topic><topic>LIVER</topic><topic>MAMMALS</topic><topic>MAN</topic><topic>MATERIALS</topic><topic>Medical sciences</topic><topic>MILK</topic><topic>NETHERLANDS</topic><topic>ORGANIC CHLORINE COMPOUNDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC HALOGEN COMPOUNDS</topic><topic>ORGANIC OXYGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>PRIMATES</topic><topic>RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT</topic><topic>Toxicology</topic><topic>UPTAKE</topic><topic>VERTEBRATES</topic><topic>WESTERN EUROPE</topic><topic>WOMEN</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van den Berg, Martin</creatorcontrib><creatorcontrib>van der Wielen, Frans W.M.</creatorcontrib><creatorcontrib>Olie, Kees</creatorcontrib><creatorcontrib>van Boxtel, Chris.J.</creatorcontrib><creatorcontrib>Univ. of Amsterdam, Netherlands</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>OSTI.GOV</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van den Berg, Martin</au><au>van der Wielen, Frans W.M.</au><au>Olie, Kees</au><au>van Boxtel, Chris.J.</au><aucorp>Univ. of Amsterdam, Netherlands</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The presence of PCDDs and PCDFs in human breast milk from the Netherlands</atitle><jtitle>Chemosphere (Oxford)</jtitle><date>1986</date><risdate>1986</risdate><volume>15</volume><issue>6</issue><spage>693</spage><epage>706</epage><pages>693-706</pages><issn>0045-6535</issn><eissn>1879-1298</eissn><coden>CMSHAF</coden><abstract>Sixteen individual and two pooled human milk samples were analyzed for PCDDs and PCDFs. All detected PCDD and PCDF congeners had a 2,3,7,8-chlorine substitution pattern.
The PCDDs and PCDFs were associated with the lipid fraction of the milk. Major components were 2,3,4,7,8-PnCDF (0.2 – 2.6 ppt), 1,2,3,6,7,8-HxCDD (0.2 – 5.7 ppt), 1,2,3,4,6,7,8-HpCDD (1.3 – 19.1) and OCDD (1.7 – 37.8 ppt), with concentrations on total milk basis.
Minor components were 1,2,3,7,8-PnCDD, 1,2,3,7,8,9- and 1,2,3,4,7,8- HxCDD (⩽ 1 ppt). Qualitatively and quantitatively the milk samples from the Netherlands strongly resemble those from Sweden and West-Germany. A linear relationship was found between some congeners. This correlation was highest for congeners having an equal number of chlorine atoms or those with a difference of one chlorine atom.
By using a one compartment open model for multiple doses, a maximum liver concentration of approximately 200 ppt 2,3,4,7,8-PnCDF in the neonate was calculated after six months.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/0045-6535(86)90035-4</doi><tpages>14</tpages></addata></record> |
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| ispartof | Chemosphere (Oxford), 1986, Vol.15 (6), p.693-706 |
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| subjects | 560306 - Chemicals Metabolism & Toxicology- Man- (-1987) AGE GROUPS ANIMALS AROMATICS BENZOFURANS Biological and medical sciences BIOLOGICAL MATERIALS BODY BODY FLUIDS CHEMICAL ANALYSIS CHILDREN CHLORINATED AROMATIC HYDROCARBONS DIGESTIVE SYSTEM Environmental pollutants toxicology EUROPE FEMALES FOOD FURANS General aspects GLANDS HALOGENATED AROMATIC HYDROCARBONS HETEROCYCLIC COMPOUNDS INFANTS LACTATION LIVER MAMMALS MAN MATERIALS Medical sciences MILK NETHERLANDS ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Toxicology UPTAKE VERTEBRATES WESTERN EUROPE WOMEN |
| title | The presence of PCDDs and PCDFs in human breast milk from the Netherlands |
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