Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat
2-Methoxyacetaldehyde (MALD) was shown to produce specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures as evidenced by morphological changes to these cells, an increase in germ-cell detachment and leakage of the pachytene spermatocyte marker enzyme lactate dehydrog...
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| Veröffentlicht in: | Toxicology letters 1986-07, Vol.32 (1), p.73-80 |
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| container_title | Toxicology letters |
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| creator | Foster, Paul M.D. Blackburn, Diane M. Moore, Richard B. Lloyd, Sara C. |
| description | 2-Methoxyacetaldehyde (MALD) was shown to produce specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures as evidenced by morphological changes to these cells, an increase in germ-cell detachment and leakage of the pachytene spermatocyte marker enzyme lactate dehydrogenase-X. These effects occurred at concentrations where the known testicular toxicant, 2-methoxyacetic acid (MAA) was without effect (0.2 and 0.5 mM). In vivo, MALD also produced the characteristic testicular lesion reported previously for MAA and its parent compound ethylene glycol monomethyl ether (EGME). It is likely that MALD plays an important role in EGME-induced testicular toxicity. |
| doi_str_mv | 10.1016/0378-4274(86)90051-2 |
| format | Article |
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These effects occurred at concentrations where the known testicular toxicant, 2-methoxyacetic acid (MAA) was without effect (0.2 and 0.5 mM). In vivo, MALD also produced the characteristic testicular lesion reported previously for MAA and its parent compound ethylene glycol monomethyl ether (EGME). It is likely that MALD plays an important role in EGME-induced testicular toxicity.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(86)90051-2</identifier><identifier>PMID: 3738932</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>2-Methoxyacetic acid ; Acetaldehyde - analogs & derivatives ; Acetaldehyde - toxicity ; Animals ; Dose-Response Relationship, Drug ; Ethylene Glycols - metabolism ; Ethylene Glycols - toxicity ; glycol ether ; L-Lactate Dehydrogenase - analysis ; LDH-X ; Male ; Rats ; Rats, Inbred Strains ; spermatocyte toxicity ; Spermatocytes - drug effects ; Spermatocytes - enzymology ; testis ; Testis - drug effects ; Testis - pathology</subject><ispartof>Toxicology letters, 1986-07, Vol.32 (1), p.73-80</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-abf83254563dcbc5ad1b90c3d694ceef7e3eb2701a7165a335478b04f645e9953</citedby><cites>FETCH-LOGICAL-c388t-abf83254563dcbc5ad1b90c3d694ceef7e3eb2701a7165a335478b04f645e9953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(86)90051-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3738932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foster, Paul M.D.</creatorcontrib><creatorcontrib>Blackburn, Diane M.</creatorcontrib><creatorcontrib>Moore, Richard B.</creatorcontrib><creatorcontrib>Lloyd, Sara C.</creatorcontrib><title>Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>2-Methoxyacetaldehyde (MALD) was shown to produce specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures as evidenced by morphological changes to these cells, an increase in germ-cell detachment and leakage of the pachytene spermatocyte marker enzyme lactate dehydrogenase-X. These effects occurred at concentrations where the known testicular toxicant, 2-methoxyacetic acid (MAA) was without effect (0.2 and 0.5 mM). In vivo, MALD also produced the characteristic testicular lesion reported previously for MAA and its parent compound ethylene glycol monomethyl ether (EGME). It is likely that MALD plays an important role in EGME-induced testicular toxicity.</description><subject>2-Methoxyacetic acid</subject><subject>Acetaldehyde - analogs & derivatives</subject><subject>Acetaldehyde - toxicity</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethylene Glycols - metabolism</subject><subject>Ethylene Glycols - toxicity</subject><subject>glycol ether</subject><subject>L-Lactate Dehydrogenase - analysis</subject><subject>LDH-X</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>spermatocyte toxicity</subject><subject>Spermatocytes - drug effects</subject><subject>Spermatocytes - enzymology</subject><subject>testis</subject><subject>Testis - drug effects</subject><subject>Testis - pathology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LHTEUhkNp0avtP1DIqig4bTL53ggi_QKhG7sOmcwZjWQm1yS3OP--M96Ly64S8j7nhPdB6IySL5RQ-ZUwpRveKn6h5aUhRNCmfYc2VCvTMCrNe7R5Q47RSSlPhBDJpThCR0wxbVi7QeUeSg1-F13GNb0EH-qM04DbZoT6mF5m56G62MPj3MMVdnibSgldBLzkrksxVFj5BZ4jTIAf4uxTxGOa0vj6uEaQr3CY8HLB2dWP6MPgYoFPh_MU_fn-7f72Z3P3-8ev25u7xjOta-O6QbNWcCFZ7zsvXE87QzzrpeEeYFDAoGsVoU5RKRxjgivdET5ILsAYwU7R5_3ebU7Pu6WnHUPxEKObIO2KpZwbpmS7gHwP-ry0yzDYbQ6jy7OlxK6u7SrSriKtlvbVtV3Hzg_7d90I_dvQQe6SX-9zWEr-DZBt8QEmD33I4KvtU_j_B_8AG4aPoA</recordid><startdate>19860701</startdate><enddate>19860701</enddate><creator>Foster, Paul M.D.</creator><creator>Blackburn, Diane M.</creator><creator>Moore, Richard B.</creator><creator>Lloyd, Sara C.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19860701</creationdate><title>Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat</title><author>Foster, Paul M.D. ; Blackburn, Diane M. ; Moore, Richard B. ; Lloyd, Sara C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-abf83254563dcbc5ad1b90c3d694ceef7e3eb2701a7165a335478b04f645e9953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>2-Methoxyacetic acid</topic><topic>Acetaldehyde - analogs & derivatives</topic><topic>Acetaldehyde - toxicity</topic><topic>Animals</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethylene Glycols - metabolism</topic><topic>Ethylene Glycols - toxicity</topic><topic>glycol ether</topic><topic>L-Lactate Dehydrogenase - analysis</topic><topic>LDH-X</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>spermatocyte toxicity</topic><topic>Spermatocytes - drug effects</topic><topic>Spermatocytes - enzymology</topic><topic>testis</topic><topic>Testis - drug effects</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foster, Paul M.D.</creatorcontrib><creatorcontrib>Blackburn, Diane M.</creatorcontrib><creatorcontrib>Moore, Richard B.</creatorcontrib><creatorcontrib>Lloyd, Sara C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foster, Paul M.D.</au><au>Blackburn, Diane M.</au><au>Moore, Richard B.</au><au>Lloyd, Sara C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>32</volume><issue>1</issue><spage>73</spage><epage>80</epage><pages>73-80</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>2-Methoxyacetaldehyde (MALD) was shown to produce specific cellular toxicity to pachytene spermatocytes in mixed testicular cell cultures as evidenced by morphological changes to these cells, an increase in germ-cell detachment and leakage of the pachytene spermatocyte marker enzyme lactate dehydrogenase-X. These effects occurred at concentrations where the known testicular toxicant, 2-methoxyacetic acid (MAA) was without effect (0.2 and 0.5 mM). In vivo, MALD also produced the characteristic testicular lesion reported previously for MAA and its parent compound ethylene glycol monomethyl ether (EGME). It is likely that MALD plays an important role in EGME-induced testicular toxicity.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>3738932</pmid><doi>10.1016/0378-4274(86)90051-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1986-07, Vol.32 (1), p.73-80 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14493762 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 2-Methoxyacetic acid Acetaldehyde - analogs & derivatives Acetaldehyde - toxicity Animals Dose-Response Relationship, Drug Ethylene Glycols - metabolism Ethylene Glycols - toxicity glycol ether L-Lactate Dehydrogenase - analysis LDH-X Male Rats Rats, Inbred Strains spermatocyte toxicity Spermatocytes - drug effects Spermatocytes - enzymology testis Testis - drug effects Testis - pathology |
| title | Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat |
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