Vascularization and bone regeneration in a critical sized defect using 2- N ,6- O- sulfated chitosan nanoparticles incorporating BMP-2

Abstract An ideal bone tissue engineering graft should have both excellent pro-osteogenesis and pro-angiogenesis to rapidly realize the bone regeneration in vivo . To meet this goal, 2- N ,6 -O- sulfated chitosan (26SCS) based nanoparticle (S-NP) was successfully developed and showed a dose-dependen...

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