Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma
Background Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognosti...
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| Veröffentlicht in: | The Annals of thoracic surgery 2013-11, Vol.96 (5), p.1790-1794 |
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| creator | Ikeda, Koei, MD, PhD Shiraishi, Kenji, MD, PhD Eguchi, Ayami, MT Shibata, Hidekatsu, MD, PhD Yoshimoto, Kentaro, MD, PhD Mori, Takeshi, MD, PhD Baba, Yoshifumi, MD, PhD Baba, Hideo, MD, PhD Suzuki, Makoto, MD, PhD |
| description | Background Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma. Methods A consecutive series of 211 lung adenocarcinoma patients who underwent curative resections without any preoperative chemotherapy or radiotherapy at Kumamoto University Hospital between April 2010 and December 2012 were included. The LINE-1 methylation levels were quantified in tumor and noncancerous tissue by Pyrosequencing assay. Results Higher histologic grade and positive findings for vascular invasion were significantly associated with lower methylation levels. The disease-free survival in the hypomethylation group was significantly shorter than that of the non-hypomethylation group. The prognostic difference was more obvious in advanced cases (stage II, III) than in stage I cases. Conclusions The LINE-1 methylation level is associated with histologic grade and vascular invasion of lung adenocarcinoma. Additionally, LINE-1 hypomethylation is a useful biomarker to predict early recurrence of lung adenocarcinoma. |
| doi_str_mv | 10.1016/j.athoracsur.2013.06.035 |
| format | Article |
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Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma. Methods A consecutive series of 211 lung adenocarcinoma patients who underwent curative resections without any preoperative chemotherapy or radiotherapy at Kumamoto University Hospital between April 2010 and December 2012 were included. The LINE-1 methylation levels were quantified in tumor and noncancerous tissue by Pyrosequencing assay. Results Higher histologic grade and positive findings for vascular invasion were significantly associated with lower methylation levels. The disease-free survival in the hypomethylation group was significantly shorter than that of the non-hypomethylation group. The prognostic difference was more obvious in advanced cases (stage II, III) than in stage I cases. Conclusions The LINE-1 methylation level is associated with histologic grade and vascular invasion of lung adenocarcinoma. Additionally, LINE-1 hypomethylation is a useful biomarker to predict early recurrence of lung adenocarcinoma.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2013.06.035</identifier><identifier>PMID: 23998411</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma of Lung ; Aged ; Cardiothoracic Surgery ; DNA Methylation ; Female ; Humans ; Long Interspersed Nucleotide Elements ; Lung Neoplasms - genetics ; Male ; Prognosis ; Surgery</subject><ispartof>The Annals of thoracic surgery, 2013-11, Vol.96 (5), p.1790-1794</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2013 The Society of Thoracic Surgeons</rights><rights>Copyright © 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-c48c38706f3d58fb241c71552a1e736e38e4a6ba74bf376de8b8257eebe4fcf63</citedby><cites>FETCH-LOGICAL-c429t-c48c38706f3d58fb241c71552a1e736e38e4a6ba74bf376de8b8257eebe4fcf63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23998411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Koei, MD, PhD</creatorcontrib><creatorcontrib>Shiraishi, Kenji, MD, PhD</creatorcontrib><creatorcontrib>Eguchi, Ayami, MT</creatorcontrib><creatorcontrib>Shibata, Hidekatsu, MD, PhD</creatorcontrib><creatorcontrib>Yoshimoto, Kentaro, MD, PhD</creatorcontrib><creatorcontrib>Mori, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Baba, Yoshifumi, MD, PhD</creatorcontrib><creatorcontrib>Baba, Hideo, MD, PhD</creatorcontrib><creatorcontrib>Suzuki, Makoto, MD, PhD</creatorcontrib><title>Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma. Methods A consecutive series of 211 lung adenocarcinoma patients who underwent curative resections without any preoperative chemotherapy or radiotherapy at Kumamoto University Hospital between April 2010 and December 2012 were included. The LINE-1 methylation levels were quantified in tumor and noncancerous tissue by Pyrosequencing assay. Results Higher histologic grade and positive findings for vascular invasion were significantly associated with lower methylation levels. The disease-free survival in the hypomethylation group was significantly shorter than that of the non-hypomethylation group. The prognostic difference was more obvious in advanced cases (stage II, III) than in stage I cases. Conclusions The LINE-1 methylation level is associated with histologic grade and vascular invasion of lung adenocarcinoma. Additionally, LINE-1 hypomethylation is a useful biomarker to predict early recurrence of lung adenocarcinoma.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma of Lung</subject><subject>Aged</subject><subject>Cardiothoracic Surgery</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Humans</subject><subject>Long Interspersed Nucleotide Elements</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Prognosis</subject><subject>Surgery</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS1ERYfCKyAv2UzwX5xkgzRUhY40opUKYmk5zk3HQ2IH26k0b8Oz8GQ4mgISqy5s68rnnKv7XYQwJQUlVL47FDrtfdAmzqFghPKCyILw8hla0bJka8nK5jlaEUL4WjRVeY5exnjIJcvfL9A5401TC0pXaNp5d4-3LkGIUz7Q4c-zGcAn2wG-GmAElzDF18fJj5D2x0En6x3eRryJ0RurU7Z8s2mPb70P-Db4e-ejjb9--h7v5hy-6cB5o4Oxzo_6FTrr9RDh9eN7gb5-vPpyeb3e3XzaXm52ayNYk_JdG15XRPa8K-u-ZYKaaplNU6i4BF6D0LLVlWh7XskO6rZmZQXQguhNL_kFenvKnYL_MUNMarTRwDBoB36OigrRsKohtcjS-iQ1wccYoFdTsKMOR0WJWnirg_rHWy28FZEq887WN49d5naE7q_xD-As-HASQJ71wUJQ0VhwBjobwCTVefuULu__CzGDddbo4TscIR78HFxmqaiKTBF1t-x9WTvlOUQyzn8DFiKuOA</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Ikeda, Koei, MD, PhD</creator><creator>Shiraishi, Kenji, MD, PhD</creator><creator>Eguchi, Ayami, MT</creator><creator>Shibata, Hidekatsu, MD, PhD</creator><creator>Yoshimoto, Kentaro, MD, PhD</creator><creator>Mori, Takeshi, MD, PhD</creator><creator>Baba, Yoshifumi, MD, PhD</creator><creator>Baba, Hideo, MD, PhD</creator><creator>Suzuki, Makoto, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma</title><author>Ikeda, Koei, MD, PhD ; Shiraishi, Kenji, MD, PhD ; Eguchi, Ayami, MT ; Shibata, Hidekatsu, MD, PhD ; Yoshimoto, Kentaro, MD, PhD ; Mori, Takeshi, MD, PhD ; Baba, Yoshifumi, MD, PhD ; Baba, Hideo, MD, PhD ; Suzuki, Makoto, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-c48c38706f3d58fb241c71552a1e736e38e4a6ba74bf376de8b8257eebe4fcf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma of Lung</topic><topic>Aged</topic><topic>Cardiothoracic Surgery</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Humans</topic><topic>Long Interspersed Nucleotide Elements</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Prognosis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Koei, MD, PhD</creatorcontrib><creatorcontrib>Shiraishi, Kenji, MD, PhD</creatorcontrib><creatorcontrib>Eguchi, Ayami, MT</creatorcontrib><creatorcontrib>Shibata, Hidekatsu, MD, PhD</creatorcontrib><creatorcontrib>Yoshimoto, Kentaro, MD, PhD</creatorcontrib><creatorcontrib>Mori, Takeshi, MD, PhD</creatorcontrib><creatorcontrib>Baba, Yoshifumi, MD, PhD</creatorcontrib><creatorcontrib>Baba, Hideo, MD, PhD</creatorcontrib><creatorcontrib>Suzuki, Makoto, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Koei, MD, PhD</au><au>Shiraishi, Kenji, MD, PhD</au><au>Eguchi, Ayami, MT</au><au>Shibata, Hidekatsu, MD, PhD</au><au>Yoshimoto, Kentaro, MD, PhD</au><au>Mori, Takeshi, MD, PhD</au><au>Baba, Yoshifumi, MD, PhD</au><au>Baba, Hideo, MD, PhD</au><au>Suzuki, Makoto, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>96</volume><issue>5</issue><spage>1790</spage><epage>1794</epage><pages>1790-1794</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Background Genome-wide DNA hypomethylation is known to play important roles in genomic instability and carcinogenesis. Methylation in long interspersed nucleotide element 1 (LINE-1) is a good indicator of the global DNA methylation level within a cell. The aim of this study was to evaluate prognostic significance of LINE-1 hypomethylation in lung adenocarcinoma. Methods A consecutive series of 211 lung adenocarcinoma patients who underwent curative resections without any preoperative chemotherapy or radiotherapy at Kumamoto University Hospital between April 2010 and December 2012 were included. The LINE-1 methylation levels were quantified in tumor and noncancerous tissue by Pyrosequencing assay. Results Higher histologic grade and positive findings for vascular invasion were significantly associated with lower methylation levels. The disease-free survival in the hypomethylation group was significantly shorter than that of the non-hypomethylation group. The prognostic difference was more obvious in advanced cases (stage II, III) than in stage I cases. Conclusions The LINE-1 methylation level is associated with histologic grade and vascular invasion of lung adenocarcinoma. Additionally, LINE-1 hypomethylation is a useful biomarker to predict early recurrence of lung adenocarcinoma.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23998411</pmid><doi>10.1016/j.athoracsur.2013.06.035</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma - genetics Adenocarcinoma of Lung Aged Cardiothoracic Surgery DNA Methylation Female Humans Long Interspersed Nucleotide Elements Lung Neoplasms - genetics Male Prognosis Surgery |
| title | Long Interspersed Nucleotide Element 1 Hypomethylation Is Associated With Poor Prognosis of Lung Adenocarcinoma |
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