The possibility that requiring high-dose olanzapine cannot be explained by pharmacokinetics in the treatment of acute-phase schizophrenia

Abstract We examined clinical characteristics including serum olanzapine concentrations for acute schizophrenia patients who required above conventional doses. We performed a rater-blinded, randomized clinical trial in 12 psychiatric emergency sites. Eligible patients were 18–64 years old and met di...

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Veröffentlicht in:	Psychiatry research 2013-12, Vol.210 (2), p.396-401
Hauptverfasser:	Hatta, Kotaro, Takebayashi, Hiroshi, Sudo, Yasuhiko, Katayama, Shigemasa, Kasuya, Masataka, Shirai, Yutaka, Morikawa, Fumiyoshi, Nakase, Reiko, Nakamura, Masato, Ito, Shin, Kuga, Hironori, Nakamura, Mitsuru, Ohnuma, Tohru, Usui, Chie, Nakamura, Hiroyuki, Hirata, Toyoaki, Sawa, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Adult and adolescent clinical studies Antipsychotic Agents - administration & dosage Antipsychotic Agents - blood Benzodiazepines - administration & dosage Benzodiazepines - blood Biological and medical sciences Diagnostic and Statistical Manual of Mental Disorders Dose-Response Relationship, Drug Emergency Emergency Services, Psychiatric Female Follow-Up Studies Humans Male Medical sciences Middle Aged Negative symptom Neuropharmacology Pharmacology. Drug treatments Prospective Studies Psychiatric Status Rating Scales Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychotic Disorders - blood Psychotic Disorders - drug therapy Randomized clinical trial Risperidone Risperidone - administration & dosage Risperidone - therapeutic use Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy Schizophrenic Psychology Serum concentration Young Adult
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