Clinical pregnancy after uterus transplantation
Objective To present the first clinical pregnancy after uterus transplantation. Design Case study. Setting Tertiary center. Patient(s) A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s) Eighteen months after...
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| Veröffentlicht in: | Fertility and sterility 2013-11, Vol.100 (5), p.1358-1363 |
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| creator | Erman Akar, Munire, M.D Ozkan, Omer, M.D Aydinuraz, Batu, M.D Dirican, Kerem, Ph.D Cincik, Mehmet, M.D Mendilcioglu, Inanc, M.D Simsek, Mehmet, M.D Gunseren, Filiz, M.D Kocak, Huseyin, M.D Ciftcioglu, Akif, M.D Gecici, Omer, M.D Ozkan, Ozlenen, M.D |
| description | Objective To present the first clinical pregnancy after uterus transplantation. Design Case study. Setting Tertiary center. Patient(s) A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s) Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. Main Outcome Measure(s) Implantation of embryo in an allografted human uterus. Result(s) The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. Conclusion(s) We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works. |
| doi_str_mv | 10.1016/j.fertnstert.2013.06.027 |
| format | Article |
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Design Case study. Setting Tertiary center. Patient(s) A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s) Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. Main Outcome Measure(s) Implantation of embryo in an allografted human uterus. Result(s) The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. Conclusion(s) We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2013.06.027</identifier><identifier>PMID: 23830110</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>46, XX Disorders of Sex Development - physiopathology ; 46, XX Disorders of Sex Development - surgery ; Abortion, Spontaneous - etiology ; case studies ; clinical pregnancy ; Congenital Abnormalities - physiopathology ; Congenital Abnormalities - surgery ; Embryo Implantation ; Embryo Transfer ; endometrium ; Female ; Fertility ; Fertility Agents, Female - therapeutic use ; Fertilization in Vitro ; Gestational Age ; Humans ; Infertility, Female - physiopathology ; Infertility, Female - surgery ; Internal Medicine ; Mullerian Ducts - abnormalities ; Mullerian Ducts - physiopathology ; Mullerian Ducts - surgery ; Obstetrics and Gynecology ; patients ; Pregnancy ; Treatment Outcome ; ultrasonics ; uterine factor infertility ; Uterus - abnormalities ; Uterus - physiopathology ; Uterus - surgery ; Uterus transplantation ; Young Adult</subject><ispartof>Fertility and sterility, 2013-11, Vol.100 (5), p.1358-1363</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2013 American Society for Reproductive Medicine</rights><rights>Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-b5144bf8ef113a4096e48333082270ae45a60eafffe7acdf8a4eb59916c68153</citedby><cites>FETCH-LOGICAL-c503t-b5144bf8ef113a4096e48333082270ae45a60eafffe7acdf8a4eb59916c68153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028213007279$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23830110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erman Akar, Munire, M.D</creatorcontrib><creatorcontrib>Ozkan, Omer, M.D</creatorcontrib><creatorcontrib>Aydinuraz, Batu, M.D</creatorcontrib><creatorcontrib>Dirican, Kerem, Ph.D</creatorcontrib><creatorcontrib>Cincik, Mehmet, M.D</creatorcontrib><creatorcontrib>Mendilcioglu, Inanc, M.D</creatorcontrib><creatorcontrib>Simsek, Mehmet, M.D</creatorcontrib><creatorcontrib>Gunseren, Filiz, M.D</creatorcontrib><creatorcontrib>Kocak, Huseyin, M.D</creatorcontrib><creatorcontrib>Ciftcioglu, Akif, M.D</creatorcontrib><creatorcontrib>Gecici, Omer, M.D</creatorcontrib><creatorcontrib>Ozkan, Ozlenen, M.D</creatorcontrib><title>Clinical pregnancy after uterus transplantation</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To present the first clinical pregnancy after uterus transplantation. Design Case study. Setting Tertiary center. Patient(s) A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s) Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. Main Outcome Measure(s) Implantation of embryo in an allografted human uterus. Result(s) The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. Conclusion(s) We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. 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Ozkan, Omer, M.D ; Aydinuraz, Batu, M.D ; Dirican, Kerem, Ph.D ; Cincik, Mehmet, M.D ; Mendilcioglu, Inanc, M.D ; Simsek, Mehmet, M.D ; Gunseren, Filiz, M.D ; Kocak, Huseyin, M.D ; Ciftcioglu, Akif, M.D ; Gecici, Omer, M.D ; Ozkan, Ozlenen, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-b5144bf8ef113a4096e48333082270ae45a60eafffe7acdf8a4eb59916c68153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>46, XX Disorders of Sex Development - physiopathology</topic><topic>46, XX Disorders of Sex Development - surgery</topic><topic>Abortion, Spontaneous - etiology</topic><topic>case studies</topic><topic>clinical pregnancy</topic><topic>Congenital Abnormalities - physiopathology</topic><topic>Congenital Abnormalities - surgery</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>endometrium</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertility Agents, Female - therapeutic use</topic><topic>Fertilization in Vitro</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infertility, Female - physiopathology</topic><topic>Infertility, Female - surgery</topic><topic>Internal Medicine</topic><topic>Mullerian Ducts - abnormalities</topic><topic>Mullerian Ducts - physiopathology</topic><topic>Mullerian Ducts - surgery</topic><topic>Obstetrics and Gynecology</topic><topic>patients</topic><topic>Pregnancy</topic><topic>Treatment Outcome</topic><topic>ultrasonics</topic><topic>uterine factor infertility</topic><topic>Uterus - abnormalities</topic><topic>Uterus - physiopathology</topic><topic>Uterus - surgery</topic><topic>Uterus transplantation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erman Akar, Munire, M.D</creatorcontrib><creatorcontrib>Ozkan, Omer, M.D</creatorcontrib><creatorcontrib>Aydinuraz, Batu, M.D</creatorcontrib><creatorcontrib>Dirican, Kerem, Ph.D</creatorcontrib><creatorcontrib>Cincik, Mehmet, M.D</creatorcontrib><creatorcontrib>Mendilcioglu, Inanc, M.D</creatorcontrib><creatorcontrib>Simsek, Mehmet, M.D</creatorcontrib><creatorcontrib>Gunseren, Filiz, M.D</creatorcontrib><creatorcontrib>Kocak, Huseyin, M.D</creatorcontrib><creatorcontrib>Ciftcioglu, Akif, M.D</creatorcontrib><creatorcontrib>Gecici, Omer, M.D</creatorcontrib><creatorcontrib>Ozkan, Ozlenen, M.D</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erman Akar, Munire, M.D</au><au>Ozkan, Omer, M.D</au><au>Aydinuraz, Batu, M.D</au><au>Dirican, Kerem, Ph.D</au><au>Cincik, Mehmet, M.D</au><au>Mendilcioglu, Inanc, M.D</au><au>Simsek, Mehmet, M.D</au><au>Gunseren, Filiz, M.D</au><au>Kocak, Huseyin, M.D</au><au>Ciftcioglu, Akif, M.D</au><au>Gecici, Omer, M.D</au><au>Ozkan, Ozlenen, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical pregnancy after uterus transplantation</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>100</volume><issue>5</issue><spage>1358</spage><epage>1363</epage><pages>1358-1363</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Objective To present the first clinical pregnancy after uterus transplantation. Design Case study. Setting Tertiary center. Patient(s) A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. Intervention(s) Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. Main Outcome Measure(s) Implantation of embryo in an allografted human uterus. Result(s) The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. Conclusion(s) We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23830110</pmid><doi>10.1016/j.fertnstert.2013.06.027</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 46, XX Disorders of Sex Development - physiopathology 46, XX Disorders of Sex Development - surgery Abortion, Spontaneous - etiology case studies clinical pregnancy Congenital Abnormalities - physiopathology Congenital Abnormalities - surgery Embryo Implantation Embryo Transfer endometrium Female Fertility Fertility Agents, Female - therapeutic use Fertilization in Vitro Gestational Age Humans Infertility, Female - physiopathology Infertility, Female - surgery Internal Medicine Mullerian Ducts - abnormalities Mullerian Ducts - physiopathology Mullerian Ducts - surgery Obstetrics and Gynecology patients Pregnancy Treatment Outcome ultrasonics uterine factor infertility Uterus - abnormalities Uterus - physiopathology Uterus - surgery Uterus transplantation Young Adult |
| title | Clinical pregnancy after uterus transplantation |
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