Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT sub(2) receptor in A sub(7)r sub(5) smooth muscle cells
Serotonin (5-HT) induces inositol phosphate production and the efflux of super(45)Ca super(2+) in a smooth muscle cell line (A sub(7)r sub(5)) derived from rat aorta. The effects were pharmacologically characterised and compared to data obtained in radioligand binding studies performed with the 5-HT...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1986-01, Vol.333 (2), p.98-103 |
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| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
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| creator | Doyle, V M Creba, JA Rueegg, U T Hoyer, D |
| description | Serotonin (5-HT) induces inositol phosphate production and the efflux of super(45)Ca super(2+) in a smooth muscle cell line (A sub(7)r sub(5)) derived from rat aorta. The effects were pharmacologically characterised and compared to data obtained in radioligand binding studies performed with the 5-HT sub(2) ligand ( super(3)H)ketanserin in rat brain cortex membranes. 5-HT causes in increase in the levels of inositol trisphosphate (InsP sub(3)), inositol bisphosphate (InsP sub(2)) and inositol phosphate (InsP sub(1)). 5-HT stimulated the efflux of super(45)Ca super(2+) from preloaded cells. There was a very good correlation between antagonism of Ca super(2+) release and 5-HT sub(2) binding as measured using a series of 13 antagonists. The data suggests that 5-HT mobilises intracellular Ca super(2+) via the production of InsP sub(3) in this smooth muscle cell line, an effect mediated by a 5-HT sub(2) receptor. |
| format | Article |
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The effects were pharmacologically characterised and compared to data obtained in radioligand binding studies performed with the 5-HT sub(2) ligand ( super(3)H)ketanserin in rat brain cortex membranes. 5-HT causes in increase in the levels of inositol trisphosphate (InsP sub(3)), inositol bisphosphate (InsP sub(2)) and inositol phosphate (InsP sub(1)). 5-HT stimulated the efflux of super(45)Ca super(2+) from preloaded cells. There was a very good correlation between antagonism of Ca super(2+) release and 5-HT sub(2) binding as measured using a series of 13 antagonists. 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The effects were pharmacologically characterised and compared to data obtained in radioligand binding studies performed with the 5-HT sub(2) ligand ( super(3)H)ketanserin in rat brain cortex membranes. 5-HT causes in increase in the levels of inositol trisphosphate (InsP sub(3)), inositol bisphosphate (InsP sub(2)) and inositol phosphate (InsP sub(1)). 5-HT stimulated the efflux of super(45)Ca super(2+) from preloaded cells. There was a very good correlation between antagonism of Ca super(2+) release and 5-HT sub(2) binding as measured using a series of 13 antagonists. The data suggests that 5-HT mobilises intracellular Ca super(2+) via the production of InsP sub(3) in this smooth muscle cell line, an effect mediated by a 5-HT sub(2) receptor.</description><subject>calcium</subject><subject>inositol phosphates</subject><subject>rats</subject><subject>serotonin</subject><subject>serotonin S2</subject><subject>smooth muscle</subject><issn>0028-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqNjsFuwjAQRH0oEhT6D3uqmkMkJ8UQjlXVinu5I2MWZZHtDV67X9IPboj6AT2NNPNmNA9qoXXb1U276-bqUeSqtd40xizUzxcmzhwpAkWX0AoK5B5hSHwuLhNH4MuYsVBmD0PPMvQ2j5SNZwh8Ik_3jrPeUQnwTXbqm3p_ACmnl7aChA6HzGmcgbfJ3FZpUlOBBObcQyjiPIJD72WlZhfrBZ_-dKmePz8O7_t6PHUrKPkYSO6kjchFjs163e3MVr_-G_wFWLhZMw</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>Doyle, V M</creator><creator>Creba, JA</creator><creator>Rueegg, U T</creator><creator>Hoyer, D</creator><scope>7QP</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19860101</creationdate><title>Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT sub(2) receptor in A sub(7)r sub(5) smooth muscle cells</title><author>Doyle, V M ; Creba, JA ; Rueegg, U T ; Hoyer, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_144895703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>calcium</topic><topic>inositol phosphates</topic><topic>rats</topic><topic>serotonin</topic><topic>serotonin S2</topic><topic>smooth muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doyle, V M</creatorcontrib><creatorcontrib>Creba, JA</creatorcontrib><creatorcontrib>Rueegg, U T</creatorcontrib><creatorcontrib>Hoyer, D</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doyle, V M</au><au>Creba, JA</au><au>Rueegg, U T</au><au>Hoyer, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT sub(2) receptor in A sub(7)r sub(5) smooth muscle cells</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><date>1986-01-01</date><risdate>1986</risdate><volume>333</volume><issue>2</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>0028-1298</issn><abstract>Serotonin (5-HT) induces inositol phosphate production and the efflux of super(45)Ca super(2+) in a smooth muscle cell line (A sub(7)r sub(5)) derived from rat aorta. The effects were pharmacologically characterised and compared to data obtained in radioligand binding studies performed with the 5-HT sub(2) ligand ( super(3)H)ketanserin in rat brain cortex membranes. 5-HT causes in increase in the levels of inositol trisphosphate (InsP sub(3)), inositol bisphosphate (InsP sub(2)) and inositol phosphate (InsP sub(1)). 5-HT stimulated the efflux of super(45)Ca super(2+) from preloaded cells. There was a very good correlation between antagonism of Ca super(2+) release and 5-HT sub(2) binding as measured using a series of 13 antagonists. The data suggests that 5-HT mobilises intracellular Ca super(2+) via the production of InsP sub(3) in this smooth muscle cell line, an effect mediated by a 5-HT sub(2) receptor.</abstract></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-1298 |
| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 1986-01, Vol.333 (2), p.98-103 |
| issn | 0028-1298 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14489570 |
| source | Springer Journals |
| subjects | calcium inositol phosphates rats serotonin serotonin S2 smooth muscle |
| title | Serotonin increases the production of inositol phosphates and mobilises calcium via the 5-HT sub(2) receptor in A sub(7)r sub(5) smooth muscle cells |
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