Pharmacokinetics: Nanoparticle Accumulation in Angiogenic Tissues: Towards Predictable Pharmacokinetics (Small 18/2013)
D. Cramb* and co-workers report that nanoparticles circulating in angiogenic tissue partition into surrounding tissues through fenestrations in the blood vessel walls, depending on the nanoparticle properties. The dependence of the portioning rate on nanoparticle size suggests that the mechanism is...
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| Veröffentlicht in: | Small (Weinheim an der Bergstrasse, Germany) Germany), 2013-09, Vol.9 (18), p.3006-3006 |
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| container_title | Small (Weinheim an der Bergstrasse, Germany) |
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| creator | Yaehne, Kristin Tekrony, Amy Clancy, Aisling Gregoriou, Yiota Walker, John Dean, Kwin Nguyen, Trinh Doiron, Amber Rinker, Kristina Jiang, Xiao Yu Childs, Sarah Cramb, David |
| description | D. Cramb* and co-workers report that nanoparticles circulating in angiogenic tissue partition into surrounding tissues through fenestrations in the blood vessel walls, depending on the nanoparticle properties. The dependence of the portioning rate on nanoparticle size suggests that the mechanism is largely controlled by geometry and that the angiogenic blood vessels function like a size exclusion filter. This work provides insight into the mechanism of nanoparticle deposition into angiogenic tissues while also presenting a new biological model that can accelerate our understanding of nanoparticle toxicity and tumor targeting. |
| doi_str_mv | 10.1002/smll.201370106 |
| format | Article |
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Cramb* and co-workers report that nanoparticles circulating in angiogenic tissue partition into surrounding tissues through fenestrations in the blood vessel walls, depending on the nanoparticle properties. The dependence of the portioning rate on nanoparticle size suggests that the mechanism is largely controlled by geometry and that the angiogenic blood vessels function like a size exclusion filter. 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Cramb* and co-workers report that nanoparticles circulating in angiogenic tissue partition into surrounding tissues through fenestrations in the blood vessel walls, depending on the nanoparticle properties. The dependence of the portioning rate on nanoparticle size suggests that the mechanism is largely controlled by geometry and that the angiogenic blood vessels function like a size exclusion filter. 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| identifier | ISSN: 1613-6810 |
| ispartof | Small (Weinheim an der Bergstrasse, Germany), 2013-09, Vol.9 (18), p.3006-3006 |
| issn | 1613-6810 1613-6829 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | angiogenesis Blood vessels Circulating Deposition drug delivery embryos Nanocomposites Nanomaterials Nanoparticles Nanostructure Nanotechnology pharmacokinetics Toxicity |
| title | Pharmacokinetics: Nanoparticle Accumulation in Angiogenic Tissues: Towards Predictable Pharmacokinetics (Small 18/2013) |
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