Genetic models of schizophrenia and related psychotic disorders: progress and pitfalls across the methodological “minefield”

The challenge of modelling a complex and multifaceted disorder such as schizophrenia is epitomised by the considerable degree of phenotypic variability described in patients and by the absence of specific and consistent neuropathological biomarkers. The pattern and severity of a range of clinical fe...

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Veröffentlicht in:	Cell and tissue research 2013-10, Vol.354 (1), p.247-257
Hauptverfasser:	O’Tuathaigh, Colm M. P, Moran, Paula M, Waddington, John L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals biomarkers Biomedical and Life Sciences Biomedicine cognition Delusional disorder Delusions Diagnosis disease models etiology genes Genotype & phenotype Human Genetics Humans Mental disorders Mice Models, Genetic Molecular Medicine Neuropsychology Neurosciences patients Phenotype phenotypic variation Proteomics Psychotic Disorders - diagnosis Psychotic Disorders - genetics Rats Review risk rodents Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics
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