Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK/c-Jun activation

Lactic acidosis is common to most solid tumors and has been found to affect infiltrating immune cells. Here we document effector phase inhibition of cytotoxic T cells (CTLs) involving complete blockage of cytokine production and partial impairment of lytic granule exocytosis. Lactic acidosis impaire...

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Veröffentlicht in:	International journal of cancer 2012-08, Vol.131 (3), p.633-640
Hauptverfasser:	Mendler, Anna N., Hu, Bin, Prinz, Petra U., Kreutz, Marina, Gottfried, Eva, Noessner, Elfriede
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Acidosis, Lactic - metabolism adoptive T cell therapy Biological and medical sciences Cancer Cancer therapies Cell activation Cell Line, Tumor Cell therapy Cytokines cytotoxic T cells Cytotoxicity Cytotoxicity, Immunologic Effector cells effector phase inhibition Exocytosis Humans Hydrogen-Ion Concentration Interferon-gamma - biosynthesis JNK Mitogen-Activated Protein Kinases - metabolism lactic acid Lactic Acid - metabolism Lactic acidosis Lymphocytes T MAP Kinase Signaling System Medical research Medical sciences Mutation Neoplasms - immunology Neoplasms - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Receptors, Antigen, T-Cell - physiology Recovery of function Solid tumors T cell receptor signaling T cell receptors T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Tumor-infiltrating lymphocytes Tumors γ-Interferon
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