Subchronic Toxicity Evaluation of Anthraquinone in Fischer 344 Rats

Female F344 rats were exposed to anthraquinone (AQ) by dietary feed at concentrations of 0, 50, 150, 469, 938, 1875, or 3750 ppm for 2 or 13 weeks. End points evaluated included clinical observations, body weights, serum chemistry, blood AQ, gross pathology, organ weights, and select tissue histopat...

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Veröffentlicht in:	International journal of toxicology 2013-09, Vol.32 (5), p.358-367
Hauptverfasser:	Dodd, Darol E., Layko, Debra K., Cantwell, Katherine E., Willson, Gabrielle A., Thomas, Russell S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - blood Anthraquinones - pharmacokinetics Anthraquinones - toxicity Body Weight - drug effects Environmental Pollutants - blood Environmental Pollutants - pharmacokinetics Environmental Pollutants - toxicity Female Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology No-Observed-Adverse-Effect Level Organ Size - drug effects Rats Rats, Inbred F344 Spleen - drug effects Spleen - pathology Toxicity Tests, Subchronic Urinary Bladder - drug effects Urinary Bladder - pathology
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