Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing

Oncogenic fusion genes that involve kinases have proven to be effective targets for therapy in a wide range of cancers. Unfortunately, the diagnostic approaches required to identify these events are struggling to keep pace with the diverse array of genetic alterations that occur in cancer. Diagnosti...

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Veröffentlicht in:	The Journal of pathology 2013-07, Vol.230 (3), p.270-276
Hauptverfasser:	Majewski, Ian J, Mittempergher, Lorenza, Davidson, Nadia M, Bosma, Astrid, Willems, Stefan M, Horlings, Hugo M, de Rink, Iris, Greger, Liliana, Hooijer, Gerrit KJ, Peters, Dennis, Nederlof, Petra M, Hofland, Ingrid, de Jong, Jeroen, Wesseling, Jelle, Kluin, Roelof JC, Brugman, Wim, Kerkhoven, Ron, Nieboer, Frank, Roepman, Paul, Broeks, Annegien, Muley, Thomas R, Jassem, Jacek, Niklinski, Jacek, van Zandwijk, Nico, Brazma, Alvis, Oshlack, Alicia, van den Heuvel, Michel, Bernards, René
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma of Lung ALK Anaplastic Lymphoma Kinase Base Sequence Calmodulin-Binding Proteins - genetics Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cohort Studies Exons FGFR3 FGFR3-TACC3 fusion genes Gene Library High-Throughput Nucleotide Sequencing Humans In Situ Hybridization, Fluorescence kinome Lung cancer Lung Neoplasms - genetics Lung Neoplasms - pathology Membrane Proteins - genetics Microtubule-Associated Proteins - genetics Mutation Nerve Tissue Proteins - genetics Oncogene Proteins, Fusion - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, Fibroblast Growth Factor, Type 3 - genetics Sequence Analysis, RNA
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