Elevated lipogenesis in epithelial stem-like cell confers survival advantage in ductal carcinoma in situ of breast cancer

Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis. However, the exact role of lipogenesis in tumor initiation is as yet poorly understood. We examined the expression profile of key lipogenic genes in clinical sample...

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Veröffentlicht in:	Oncogene 2013-10, Vol.32 (42), p.5111-5122
Hauptverfasser:	Pandey, P R, Xing, F, Sharma, S, Watabe, M, Pai, S K, Iiizumi-Gairani, M, Fukuda, K, Hirota, S, Mo, Y-Y, Watabe, K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1059/99 631/67/71 631/80/82/23 692/699/67/1347 Animals Apoptosis Apoptosis - drug effects Biochemistry Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - prevention & control Cancer Carcinoma, Ductal Carcinoma, Intraductal, Noninfiltrating - metabolism Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Intraductal, Noninfiltrating - prevention & control Care and treatment CD44 antigen Cell Biology Cell culture Cell death Cell Line, Tumor Cell Proliferation Cell surface Cell Survival Ectopic expression Fatty acids Female Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Human Genetics Humans Internal Medicine Lipogenesis Lipogenesis - drug effects Lipogenesis - genetics Medicine Medicine & Public Health Mice Mice, Nude Oncology original-article Polyphenols Resveratrol Stem cells Stem Cells - pathology Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Stilbenes Surface markers Synthesis Testing Tumors Xenograft Model Antitumor Assays
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