Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy
A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5-10 nm, length similar to 200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated...
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| Veröffentlicht in: | Chemical science (Cambridge) 2013-01, Vol.4 (11), p.4168-4174 |
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| container_title | Chemical science (Cambridge) |
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| creator | Mandal, Subhra Eksteen-Akeroyd, Zaskia H. Jacobs, Monique J. Hammink, Roel Koepf, Matthieu Lambeck, Annechien J. A. van Hest, Jan C. M. Wilson, Christopher J. Blank, Kerstin Figdor, Carl G. Rowan, Alan E. |
| description | A new class of antibody-functionalized, semi-flexible and filamentous polymers (diameter 5-10 nm, length similar to 200 nm) with a controlled persistence length, a high degree of stereoregularity and the potential for multiple simultaneous receptor interactions has been developed. We have decorated these highly controlled, semi-stiff polymers with T cell activating anti-CD3 antibodies and analyzed their application potential as simple synthetic mimics of dendritic cells (sDCs). Our sDCs do not only activate T cells at significantly lower concentrations than free antibodies or rigid sphere-like counterparts (PLGA particles) but also induce a more robust T cell response. Our novel design further yields sDCs that are biocompatible and non-toxic. The observed increased efficacy highlights the importance of architectural flexibility and multivalency for modulating T cell response and cellular function in general. |
| doi_str_mv | 10.1039/c3sc51399h |
| format | Article |
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| title | Therapeutic nanoworms: towards novel synthetic dendritic cells for immunotherapy |
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