Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions
The aim of this study was to determine the effect of supercritical carbon dioxide (SC-CO2) on the crystallinity and drug release of Gelucire 44/14-based endogenous progesterone (PGN) dispersion systems. The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical mi...
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| Veröffentlicht in: | Journal of drug delivery science and technology 2013-01, Vol.23 (5), p.477-483, Article 477 |
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| container_title | Journal of drug delivery science and technology |
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| creator | Falconer, J.R. Wen, J. Zargar-Shoshtari, S. Chen, J.J. Farid, M. Young, S. Alany, R.G. |
| description | The aim of this study was to determine the effect of supercritical carbon dioxide (SC-CO2) on the crystallinity and drug release of Gelucire 44/14-based endogenous progesterone (PGN) dispersion systems. The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical microscopy. In vitro dissolution was used to determine the release kinetics of PGN, Gelucire 44/14, incorporated by a supercritical fluid (SCF) method. Release profiles were evaluated according to zero-order, first-order, Higuchi, Krosmeyer-Peppas, and dual first-order models. The dual first-order release model illustrated two distinct release rates: an initial rapid release followed by a slow diffusion of PGN from the dispersion systems. The dual first-order release model adds a new tool to the elucidation of release mechanisms from lipid and micelle-forming-based dispersion systems, where parallel processes contribute to drug release. |
| doi_str_mv | 10.1016/S1773-2247(13)50069-4 |
| format | Article |
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The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical microscopy. In vitro dissolution was used to determine the release kinetics of PGN, Gelucire 44/14, incorporated by a supercritical fluid (SCF) method. Release profiles were evaluated according to zero-order, first-order, Higuchi, Krosmeyer-Peppas, and dual first-order models. The dual first-order release model illustrated two distinct release rates: an initial rapid release followed by a slow diffusion of PGN from the dispersion systems. 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The dual first-order release model adds a new tool to the elucidation of release mechanisms from lipid and micelle-forming-based dispersion systems, where parallel processes contribute to drug release.</description><subject>Dual first order</subject><subject>Factorial design experiment</subject><subject>Mathematical iteration curves</subject><subject>Particles from gas-saturated suspensions (PGSS)</subject><subject>Process yield</subject><issn>1773-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFUUFuFDEQnANIRCFPQPIxHIbYHs94RxwQikJAipQDcLa87Z6okdde3N6I_Q8Pxbsbccglp1a3q0rlqq57p-QHJdV09V1ZO_RaG3uphvejlNPcm1fd2f_zm-6C-ZeUUlmpjJ7Pur83y4JQWeRF8G6LBQpVAh8F-LLOSQTKfyig2JYMyEzpQbRr3j6Byp6rj5ES1b3wKQhK4pFqyaJgRM94EG7cB-SKJSc8gm4x7oAKCmOulBGcI4XjA-OG-tMaiJsdppz4bfd68ZHx4mmedz-_3Py4_trf3d9-u_5818NgdO2t0tqvpderWeIEo1J2gJWelJzArvw8hnGcQzDrcRkWC2aQywTzvG4JWGlnGM67y5NuM_x71xy7DTFgjD5h3rFTxqy00oNSDTqeoFAyc8HFbQttfNk7Jd2hDHcswx1Sd2pwxzKcabyPz3hA1df2y1o8xRfZn05sbCk8EhbHQJgAQwsTqguZXlD4B8A5qLk</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Falconer, J.R.</creator><creator>Wen, J.</creator><creator>Zargar-Shoshtari, S.</creator><creator>Chen, J.J.</creator><creator>Farid, M.</creator><creator>Young, S.</creator><creator>Alany, R.G.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130101</creationdate><title>Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions</title><author>Falconer, J.R. ; Wen, J. ; Zargar-Shoshtari, S. ; Chen, J.J. ; Farid, M. ; Young, S. ; Alany, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-7122ab0a2890e6c51173c826106c78a95d559dd4b5f3f7c430f6c99bffe7079c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Dual first order</topic><topic>Factorial design experiment</topic><topic>Mathematical iteration curves</topic><topic>Particles from gas-saturated suspensions (PGSS)</topic><topic>Process yield</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Falconer, J.R.</creatorcontrib><creatorcontrib>Wen, J.</creatorcontrib><creatorcontrib>Zargar-Shoshtari, S.</creatorcontrib><creatorcontrib>Chen, J.J.</creatorcontrib><creatorcontrib>Farid, M.</creatorcontrib><creatorcontrib>Young, S.</creatorcontrib><creatorcontrib>Alany, R.G.</creatorcontrib><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of drug delivery science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Falconer, J.R.</au><au>Wen, J.</au><au>Zargar-Shoshtari, S.</au><au>Chen, J.J.</au><au>Farid, M.</au><au>Young, S.</au><au>Alany, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions</atitle><jtitle>Journal of drug delivery science and technology</jtitle><date>2013-01-01</date><risdate>2013</risdate><volume>23</volume><issue>5</issue><spage>477</spage><epage>483</epage><pages>477-483</pages><artnum>477</artnum><issn>1773-2247</issn><abstract>The aim of this study was to determine the effect of supercritical carbon dioxide (SC-CO2) on the crystallinity and drug release of Gelucire 44/14-based endogenous progesterone (PGN) dispersion systems. The light scattering from PGN crystals incorporated in Gelucire 44/14 was imaged using optical microscopy. In vitro dissolution was used to determine the release kinetics of PGN, Gelucire 44/14, incorporated by a supercritical fluid (SCF) method. Release profiles were evaluated according to zero-order, first-order, Higuchi, Krosmeyer-Peppas, and dual first-order models. The dual first-order release model illustrated two distinct release rates: an initial rapid release followed by a slow diffusion of PGN from the dispersion systems. The dual first-order release model adds a new tool to the elucidation of release mechanisms from lipid and micelle-forming-based dispersion systems, where parallel processes contribute to drug release.</abstract><pub>Elsevier B.V</pub><doi>10.1016/S1773-2247(13)50069-4</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of drug delivery science and technology, 2013-01, Vol.23 (5), p.477-483, Article 477 |
| issn | 1773-2247 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Dual first order Factorial design experiment Mathematical iteration curves Particles from gas-saturated suspensions (PGSS) Process yield |
| title | Effects of supercritical carbon dioxide processing on optical crystallinity and in vitro release of progesterone and Gelucire 44/14 solid and semi-solid dispersions |
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