Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial
We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life. Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) ≤ 4...
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| Veröffentlicht in: | The European respiratory journal 2013-11, Vol.42 (5), p.1244-1254 |
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| creator | ARZT, Michael SCHROLL, Stephan SERIES, Frederic LEWIS, Keir BENJAMIN, Amit ESCOURROU, Pierre LUIGART, Ruth KEHL, Victoria PFEIFER, Michael |
| description | We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life. Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) ≤ 40%) and SDB (apnoea/hypopnoea index ≥ 20 events · h(-1)) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks. The apnoea/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39 ± 16 versus -1 ± 13 events · h(-1); p |
| doi_str_mv | 10.1183/09031936.00083312 |
| format | Article |
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Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) ≤ 40%) and SDB (apnoea/hypopnoea index ≥ 20 events · h(-1)) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks. The apnoea/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39 ± 16 versus -1 ± 13 events · h(-1); p<0.001) with an average use of 4.5 ± 3.0 h · day(-1). Both groups showed similar improvements of the primary end-point LVEF (+3.4 ± 5 versus +3.5 ± 6%; p=0.915) assessed with echocardiography. In the ASV group, reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly greater (-360 ± 569 versus +135 ± 625 ng · mL(-1); p=0.010). No differences were observed between the groups in subjective quality of life. In patients with CHF and SDB, ASV reduced NT-proBNP levels, but improvement of LVEF or quality of life was not greater than in the control group. The data support that such patients can be randomised in large-scale, long-term trials of positive airway pressure therapy versus control to determine effects on cardiovascular outcome.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00083312</identifier><identifier>PMID: 23222879</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Aged ; Algorithms ; Biological and medical sciences ; Cardiology. Vascular system ; Continuous Positive Airway Pressure - methods ; Echocardiography ; Electrocardiography ; Electroencephalography ; Female ; Heart ; Heart Failure - complications ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; Humans ; Male ; Medical sciences ; Middle Aged ; Natriuretic Peptide, Brain - metabolism ; Peptide Fragments - metabolism ; Pilot Projects ; Pneumology ; Polysomnography ; Positive-Pressure Respiration - methods ; Quality of Life ; Respiratory system : syndromes and miscellaneous diseases ; Sleep Apnea Syndromes - complications ; Sleep Apnea Syndromes - physiopathology ; Sleep Apnea Syndromes - therapy ; Snoring ; Tidal Volume ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>The European respiratory journal, 2013-11, Vol.42 (5), p.1244-1254</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-47a5682622c417f3e273a41c3a826d9f2245aed135da2e99606198af20f1a89f3</citedby><cites>FETCH-LOGICAL-c374t-47a5682622c417f3e273a41c3a826d9f2245aed135da2e99606198af20f1a89f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27854461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23222879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARZT, Michael</creatorcontrib><creatorcontrib>SCHROLL, Stephan</creatorcontrib><creatorcontrib>SERIES, Frederic</creatorcontrib><creatorcontrib>LEWIS, Keir</creatorcontrib><creatorcontrib>BENJAMIN, Amit</creatorcontrib><creatorcontrib>ESCOURROU, Pierre</creatorcontrib><creatorcontrib>LUIGART, Ruth</creatorcontrib><creatorcontrib>KEHL, Victoria</creatorcontrib><creatorcontrib>PFEIFER, Michael</creatorcontrib><title>Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life. Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) ≤ 40%) and SDB (apnoea/hypopnoea index ≥ 20 events · h(-1)) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks. The apnoea/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39 ± 16 versus -1 ± 13 events · h(-1); p<0.001) with an average use of 4.5 ± 3.0 h · day(-1). Both groups showed similar improvements of the primary end-point LVEF (+3.4 ± 5 versus +3.5 ± 6%; p=0.915) assessed with echocardiography. In the ASV group, reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly greater (-360 ± 569 versus +135 ± 625 ng · mL(-1); p=0.010). No differences were observed between the groups in subjective quality of life. In patients with CHF and SDB, ASV reduced NT-proBNP levels, but improvement of LVEF or quality of life was not greater than in the control group. The data support that such patients can be randomised in large-scale, long-term trials of positive airway pressure therapy versus control to determine effects on cardiovascular outcome.</description><subject>Aged</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Continuous Positive Airway Pressure - methods</subject><subject>Echocardiography</subject><subject>Electrocardiography</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>Peptide Fragments - metabolism</subject><subject>Pilot Projects</subject><subject>Pneumology</subject><subject>Polysomnography</subject><subject>Positive-Pressure Respiration - methods</subject><subject>Quality of Life</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep Apnea Syndromes - therapy</subject><subject>Snoring</subject><subject>Tidal Volume</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1rHDEMhk1p6G7S_oBegi-BXGZrWd6ZcW8h5AsCvbT0OKgzMuvgHW9tT0L-fWfJbnqSkJ5XiEeIr6BWAC1-U1YhWKxXSqkWEfQHsQS0tkKl8KNY7vfVHliI05yflILaIHwSC41a67axS_H7aiqxypye4zOPxQcqPo7Sj3LDlIp05MOUWL74spE5MO8k7cbI9F2STDQOceszD7KPY0kxhLktyVP4LE4chcxfDvVM_Lq9-Xl9Xz3-uHu4vnqsemxMqUxD67rVtda9gcYh6wbJQI80DwfrtDZr4gFwPZBma2tVg23JaeWAWuvwTFy-3d2l-HfiXLr5n55DoJHjlDswptWgGmhmFN7QPsWcE7tul_yW0msHqtv77I4-u6PPOXN-OD_92fLwnjgKnIGLA0C5p-BmJb3P_7mmXRtTA_4D44J8eA</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>ARZT, Michael</creator><creator>SCHROLL, Stephan</creator><creator>SERIES, Frederic</creator><creator>LEWIS, Keir</creator><creator>BENJAMIN, Amit</creator><creator>ESCOURROU, Pierre</creator><creator>LUIGART, Ruth</creator><creator>KEHL, Victoria</creator><creator>PFEIFER, Michael</creator><general>Maney</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial</title><author>ARZT, Michael ; SCHROLL, Stephan ; SERIES, Frederic ; LEWIS, Keir ; BENJAMIN, Amit ; ESCOURROU, Pierre ; LUIGART, Ruth ; KEHL, Victoria ; PFEIFER, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-47a5682622c417f3e273a41c3a826d9f2245aed135da2e99606198af20f1a89f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Continuous Positive Airway Pressure - methods</topic><topic>Echocardiography</topic><topic>Electrocardiography</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Peptide Fragments - metabolism</topic><topic>Pilot Projects</topic><topic>Pneumology</topic><topic>Polysomnography</topic><topic>Positive-Pressure Respiration - methods</topic><topic>Quality of Life</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Sleep Apnea Syndromes - complications</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep Apnea Syndromes - therapy</topic><topic>Snoring</topic><topic>Tidal Volume</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARZT, Michael</creatorcontrib><creatorcontrib>SCHROLL, Stephan</creatorcontrib><creatorcontrib>SERIES, Frederic</creatorcontrib><creatorcontrib>LEWIS, Keir</creatorcontrib><creatorcontrib>BENJAMIN, Amit</creatorcontrib><creatorcontrib>ESCOURROU, Pierre</creatorcontrib><creatorcontrib>LUIGART, Ruth</creatorcontrib><creatorcontrib>KEHL, Victoria</creatorcontrib><creatorcontrib>PFEIFER, Michael</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARZT, Michael</au><au>SCHROLL, Stephan</au><au>SERIES, Frederic</au><au>LEWIS, Keir</au><au>BENJAMIN, Amit</au><au>ESCOURROU, Pierre</au><au>LUIGART, Ruth</au><au>KEHL, Victoria</au><au>PFEIFER, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>42</volume><issue>5</issue><spage>1244</spage><epage>1254</epage><pages>1244-1254</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>We tested the hypotheses that in patients with congestive heart failure (CHF) and sleep disordered breathing (SDB) auto-servoventilation (ASV) improves cardiac function and quality of life. Between March 2007 and September 2009, patients with stable CHF (left ventricular ejection fraction (LVEF) ≤ 40%) and SDB (apnoea/hypopnoea index ≥ 20 events · h(-1)) were randomised to receive either ASV (BiPAP ASV (Philips Respironics, Murrysville, PA, USA), n=37) and optimal medical management, or optimal medical management alone (n=35). Outcomes were assessed at baseline and 12 weeks. The apnoea/hypopnoea index assessed with polysomnography scored in one core laboratory was significantly more reduced in the ASV group (-39 ± 16 versus -1 ± 13 events · h(-1); p<0.001) with an average use of 4.5 ± 3.0 h · day(-1). Both groups showed similar improvements of the primary end-point LVEF (+3.4 ± 5 versus +3.5 ± 6%; p=0.915) assessed with echocardiography. In the ASV group, reduction of N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly greater (-360 ± 569 versus +135 ± 625 ng · mL(-1); p=0.010). No differences were observed between the groups in subjective quality of life. In patients with CHF and SDB, ASV reduced NT-proBNP levels, but improvement of LVEF or quality of life was not greater than in the control group. The data support that such patients can be randomised in large-scale, long-term trials of positive airway pressure therapy versus control to determine effects on cardiovascular outcome.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>23222879</pmid><doi>10.1183/09031936.00083312</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Algorithms Biological and medical sciences Cardiology. Vascular system Continuous Positive Airway Pressure - methods Echocardiography Electrocardiography Electroencephalography Female Heart Heart Failure - complications Heart Failure - physiopathology Heart Failure - therapy Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Male Medical sciences Middle Aged Natriuretic Peptide, Brain - metabolism Peptide Fragments - metabolism Pilot Projects Pneumology Polysomnography Positive-Pressure Respiration - methods Quality of Life Respiratory system : syndromes and miscellaneous diseases Sleep Apnea Syndromes - complications Sleep Apnea Syndromes - physiopathology Sleep Apnea Syndromes - therapy Snoring Tidal Volume Treatment Outcome Ventricular Function, Left |
| title | Auto-servoventilation in heart failure with sleep apnoea: a randomised controlled trial |
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