Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

Presenilin (PS) plays a central role in the pathogenesis of Alzheimer’s disease, and loss of PS causes progressive memory impairment and age-related neurodegeneration in the mouse cerebral cortex. In hippocampal neurons, PS is essential for neurotransmitter release, NMDA receptor-mediated responses,...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-09, Vol.110 (37), p.15091-15096
Hauptverfasser:	Wu, Bei, Yamaguchi, Hiroo, Lai, F. Anthony, Shen, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimers disease Animal memory Animals Biological and medical sciences Biological Sciences Calcium Calcium Signaling Cells, Cultured Endoplasmic Reticulum - metabolism Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Hippocampus Hippocampus - metabolism Homeostasis Medical sciences Mice Mice, Knockout Neurons Neurons - metabolism Neuropharmacology Pharmacology. Drug treatments Physiological regulation Presenilin-1 - deficiency Presenilin-1 - genetics Presenilin-1 - metabolism Presenilin-2 - deficiency Presenilin-2 - genetics Presenilin-2 - metabolism Presenilins Presynaptic Terminals - metabolism Protein isoforms Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Ryanodine Receptor Calcium Release Channel - deficiency Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism Vertebrates: nervous system and sense organs
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