Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA

TNF‐related apoptosis‐inducing ligand receptor 2 [TRAIL‐R2 or death receptor 5 (DR5)] is expressed at elevated levels in a broad range of solid tumors to mediate apoptotic signals from TRAIL or agonist antibodies. We tested the hypothesis that DR5 DNA vaccination will induce proapoptotic antibody to...

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Veröffentlicht in:	International journal of cancer 2012-12, Vol.131 (11), p.2562-2572
Hauptverfasser:	Piechocki, Marie P., Wu, Gen Sheng, Jones, Richard F., Jacob, Jennifer B., Gibson, Heather, Ethier, Stephen P., Abrams, Judith, Yagita, Hideo, Venuprasad, K, Wei, Wei-Zen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neoplasm - biosynthesis Antibodies, Neoplasm - immunology antibody Apoptosis Apoptosis - genetics Apoptosis - immunology BALB 3T3 Cells Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - therapy Cancer Cancer therapies Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Cell Growth Processes - immunology Cell Line, Tumor DNA vaccine DR5 (TRAIL-R2) Female Gynecology. Andrology. Obstetrics Humans Immune Sera - immunology Immunization Immunoglobulin G - immunology Immunoglobulins Interferon-gamma - immunology Mammary gland diseases Medical research Medical sciences Mice Mice, SCID NIH 3T3 Cells Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology T-Lymphocytes - immunology triple-negative breast cancer Tumors Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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