The essential role of PIM kinases in sarcoma growth and bone invasion

PIM kinases are a family of serine/threonine kinases composed of three different isoforms (PIM1, PIM 2 and PIM 3) that are highly homologous. Their expression is mediated by the JAK/STAT signalling pathway, providing survival and cell cycle transition signals. PIM kinases are heavily targeted for an...

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Veröffentlicht in:	Carcinogenesis (New York) 2012-08, Vol.33 (8), p.1479-1486
Hauptverfasser:	NARLIK-GRASSOW, Maja, BLANCO-APARICIO, Carmen, CECILIA, Yolanda, PEREGRINA, Sandra, GARCIA-SERELDE, Beatriz, MUNOZ-GALVAN, Sandra, CANAMERO, Marta, CARNERO, Amancio
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Methylcholanthrene Animals Biological and medical sciences Bone and Bones - pathology Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Cell Line Cell Proliferation Cells, Cultured Medical sciences Methylcholanthrene - toxicity Mice Mice, Knockout Neoplasm Invasiveness Proto-Oncogene Proteins c-pim-1 - metabolism Sarcoma, Experimental - chemically induced Sarcoma, Experimental - enzymology Sarcoma, Experimental - pathology Tumors
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