Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate

An inexorable decline in maximum heart rate (mHR) progressively limits human aerobic capacity with advancing age. This decrease in mHR results from an age-dependent reduction in “intrinsic heart rate” (iHR), which is measured during autonomic blockade. The reduced iHR indicates, by definition, that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-10, Vol.110 (44), p.18011-18016
Hauptverfasser:	Larson, Eric D., St. Clair, Joshua R., Sumner, Whitney A., Bannister, Roger A., Proenza, Cathy
Format:	Artikel
Sprache:	eng
Schlagworte:	action potentials Action Potentials - physiology Age Aging Aging - physiology Analysis of Variance Animals Biological Sciences calcium Calcium - metabolism Cardiology Current density Electric current Electric potential Electrocardiography Exercise Heart Heart rate Heart Rate - physiology humans hypertrophy ion channels Mice myocytes Myocytes, Cardiac - physiology Older adults Patch-Clamp Techniques Rectifiers Rodents Sinoatrial Node - cytology Sinoatrial Node - physiology Waveforms
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