The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways

Hesperetin, a flavonoid from citrus fruits, has several bioactivities such as anti‐inflammatory, antihypertensive, antiatherogenic effects. However, studies elucidating the role and the mechanism(s) of action of hesperetin in cervical cancer are sparse. In this study, we investigated the mechanism o...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2013-12, Vol.27 (6), p.581-592
Hauptverfasser:	Alshatwi, Ali A., Ramesh, E., Periasamy, V.S., Subash-Babu, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences cell cycle Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Survival - drug effects cervical cancer death receptor Dose-Response Relationship, Drug fas Receptor - metabolism Female Female genital diseases Flow Cytometry Gynecology. Andrology. Obstetrics hesperetin Hesperidin - administration & dosage Hesperidin - pharmacology Humans In Situ Nick-End Labeling Inhibitory Concentration 50 Medical sciences Membrane Potential, Mitochondrial - drug effects mitochondria Mitochondria - drug effects Mitochondria - metabolism Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Real-Time Polymerase Chain Reaction Time Factors Tumors Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology
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