Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells

Immunodeficient mice bearing targeted mutations in the IL2rg gene and engrafted with human immune systems are effective tools for the study of human haematopoiesis, immunity, infectious disease and transplantation biology. The most robust human immune model is generated by implantation of human feta...

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Veröffentlicht in:	Clinical and experimental immunology 2013-12, Vol.174 (3), p.372-388
Hauptverfasser:	Covassin, L, Jangalwe, S, Jouvet, N, Laning, J, Burzenski, L, Shultz, L D, Brehm, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Graft vs Host Disease - immunology Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells Humans Immunoglobulin G - blood Immunoglobulin M - blood Interleukin Receptor Common gamma Subunit - genetics Interleukin Receptor Common gamma Subunit - immunology Leukocyte Common Antigens - metabolism Lymphocyte Activation Lymphocyte Count Mice Mice, Inbred NOD Molecular Sequence Data T-Lymphocytes, Regulatory - immunology Thymus Gland - immunology Thymus Gland - transplantation
Online-Zugang:	Volltext
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