Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions
ABSTRACT Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we...
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| Veröffentlicht in: | Movement disorders 2013-10, Vol.28 (12), p.1644-1652 |
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| creator | Rosa, Manuela Fumagalli, Manuela Giannicola, Gaia Marceglia, Sara Lucchiari, Claudio Servello, Domenico Franzini, Angelo Pacchetti, Claudio Romito, Luigi Albanese, Alberto Porta, Mauro Pravettoni, Gabriella Priori, Alberto |
| description | ABSTRACT
Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision‐making task comprising conflictual trials (involving possible risk‐taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2–12 Hz) increased during economics decisions. Whereas, in patients without gambling, low‐frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low‐frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low‐frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low‐frequency subthalamic activity increases. This task‐related change suggests that the cognitive‐affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. © 2013 International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.25427 |
| format | Article |
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Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision‐making task comprising conflictual trials (involving possible risk‐taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2–12 Hz) increased during economics decisions. Whereas, in patients without gambling, low‐frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low‐frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low‐frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low‐frequency subthalamic activity increases. This task‐related change suggests that the cognitive‐affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. © 2013 International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.25427</identifier><identifier>PMID: 23554027</identifier><identifier>CODEN: MOVDEA</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Decision Making - physiology ; decision-making ; Deep Brain Stimulation ; Electrodes, Implanted ; Female ; Gambling - complications ; Gambling - physiopathology ; Gambling - psychology ; Humans ; local field potentials ; Male ; Membrane Potentials - physiology ; Middle Aged ; Movement disorders ; Parkinson Disease - complications ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; Parkinson Disease - therapy ; Parkinson's disease ; pathological gambling ; Risk-Taking ; subthalamic nucleus ; Subthalamic Nucleus - physiopathology</subject><ispartof>Movement disorders, 2013-10, Vol.28 (12), p.1644-1652</ispartof><rights>Copyright © 2013 Movement Disorder Society</rights><rights>Copyright © 2013 Movement Disorder Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3917-8c6acaeec5026a74de3967db3681754945e6de7f84f975fcf9c68b2016c0b1f73</citedby><cites>FETCH-LOGICAL-c3917-8c6acaeec5026a74de3967db3681754945e6de7f84f975fcf9c68b2016c0b1f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.25427$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.25427$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosa, Manuela</creatorcontrib><creatorcontrib>Fumagalli, Manuela</creatorcontrib><creatorcontrib>Giannicola, Gaia</creatorcontrib><creatorcontrib>Marceglia, Sara</creatorcontrib><creatorcontrib>Lucchiari, Claudio</creatorcontrib><creatorcontrib>Servello, Domenico</creatorcontrib><creatorcontrib>Franzini, Angelo</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Romito, Luigi</creatorcontrib><creatorcontrib>Albanese, Alberto</creatorcontrib><creatorcontrib>Porta, Mauro</creatorcontrib><creatorcontrib>Pravettoni, Gabriella</creatorcontrib><creatorcontrib>Priori, Alberto</creatorcontrib><title>Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>ABSTRACT
Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision‐making task comprising conflictual trials (involving possible risk‐taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2–12 Hz) increased during economics decisions. Whereas, in patients without gambling, low‐frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low‐frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low‐frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low‐frequency subthalamic activity increases. This task‐related change suggests that the cognitive‐affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. © 2013 International Parkinson and Movement Disorder Society</description><subject>Adult</subject><subject>Aged</subject><subject>Decision Making - physiology</subject><subject>decision-making</subject><subject>Deep Brain Stimulation</subject><subject>Electrodes, Implanted</subject><subject>Female</subject><subject>Gambling - complications</subject><subject>Gambling - physiopathology</subject><subject>Gambling - psychology</subject><subject>Humans</subject><subject>local field potentials</subject><subject>Male</subject><subject>Membrane Potentials - physiology</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson's disease</subject><subject>pathological gambling</subject><subject>Risk-Taking</subject><subject>subthalamic nucleus</subject><subject>Subthalamic Nucleus - physiopathology</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P1UAUxSdEA0904RcwTVygi8Lc-V925KmoQSUBZDmZTm8fg20HO22Ub-88H7AgYXWTe3_n5ORcQl4D3QdK2UHfpH0mBdNbZAGSQ2mY1M_IghojSw5G7pAXKV1TCiBBbZMdxqUUlOkFcaduuopdXAXvumLl-roLw6oIQ3Hqxl9hSHHYS0UTErqEh8XZXE9XrnN98EVMPnSdm0IcMjGPax36OMR8zAv0Ia1PL8nz1nUJX93NXXLx6eP58nN58uP4y_LopPS8Al0ar5x3iF5SppwWDfJK6abmyoCWohISVYO6NaKttGx9W3llakZBeVpDq_kuebfxvRnj7xnTZPuQPOaEA8Y5WRBCA1XM8Iy-fYRex3kccro1JSqjQEGm3m8oP8aURmztzRh6N95aoHbdu8292_-9Z_bNneNc99g8kPdFZ-BgA_wJHd4-7WS_fTi7tyw3ipAm_PugyF-xSnMt7eX3Y7uUl1_NT6Ot4P8Agveb8Q</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Rosa, Manuela</creator><creator>Fumagalli, Manuela</creator><creator>Giannicola, Gaia</creator><creator>Marceglia, Sara</creator><creator>Lucchiari, Claudio</creator><creator>Servello, Domenico</creator><creator>Franzini, Angelo</creator><creator>Pacchetti, Claudio</creator><creator>Romito, Luigi</creator><creator>Albanese, Alberto</creator><creator>Porta, Mauro</creator><creator>Pravettoni, Gabriella</creator><creator>Priori, Alberto</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions</title><author>Rosa, Manuela ; Fumagalli, Manuela ; Giannicola, Gaia ; Marceglia, Sara ; Lucchiari, Claudio ; Servello, Domenico ; Franzini, Angelo ; Pacchetti, Claudio ; Romito, Luigi ; Albanese, Alberto ; Porta, Mauro ; Pravettoni, Gabriella ; Priori, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3917-8c6acaeec5026a74de3967db3681754945e6de7f84f975fcf9c68b2016c0b1f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Decision Making - physiology</topic><topic>decision-making</topic><topic>Deep Brain Stimulation</topic><topic>Electrodes, Implanted</topic><topic>Female</topic><topic>Gambling - complications</topic><topic>Gambling - physiopathology</topic><topic>Gambling - psychology</topic><topic>Humans</topic><topic>local field potentials</topic><topic>Male</topic><topic>Membrane Potentials - physiology</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson Disease - therapy</topic><topic>Parkinson's disease</topic><topic>pathological gambling</topic><topic>Risk-Taking</topic><topic>subthalamic nucleus</topic><topic>Subthalamic Nucleus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosa, Manuela</creatorcontrib><creatorcontrib>Fumagalli, Manuela</creatorcontrib><creatorcontrib>Giannicola, Gaia</creatorcontrib><creatorcontrib>Marceglia, Sara</creatorcontrib><creatorcontrib>Lucchiari, Claudio</creatorcontrib><creatorcontrib>Servello, Domenico</creatorcontrib><creatorcontrib>Franzini, Angelo</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Romito, Luigi</creatorcontrib><creatorcontrib>Albanese, Alberto</creatorcontrib><creatorcontrib>Porta, Mauro</creatorcontrib><creatorcontrib>Pravettoni, Gabriella</creatorcontrib><creatorcontrib>Priori, Alberto</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosa, Manuela</au><au>Fumagalli, Manuela</au><au>Giannicola, Gaia</au><au>Marceglia, Sara</au><au>Lucchiari, Claudio</au><au>Servello, Domenico</au><au>Franzini, Angelo</au><au>Pacchetti, Claudio</au><au>Romito, Luigi</au><au>Albanese, Alberto</au><au>Porta, Mauro</au><au>Pravettoni, Gabriella</au><au>Priori, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2013-10</date><risdate>2013</risdate><volume>28</volume><issue>12</issue><spage>1644</spage><epage>1652</epage><pages>1644-1652</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><coden>MOVDEA</coden><abstract>ABSTRACT
Pathological gambling develops in up to 8% of patients with Parkinson's disease. Although the pathophysiology of gambling remains unclear, several findings argue for a dysfunction in the basal ganglia circuits. To clarify the role of the subthalamic nucleus in pathological gambling, we studied its activity during economics decisions. We analyzed local field potentials recorded from deep brain stimulation electrodes in the subthalamic nucleus while parkinsonian patients with (n = 8) and without (n = 9) pathological gambling engaged in an economics decision‐making task comprising conflictual trials (involving possible risk‐taking) and non conflictual trials. In all parkinsonian patients, subthalamic low frequencies (2–12 Hz) increased during economics decisions. Whereas, in patients without gambling, low‐frequency oscillations exhibited a similar pattern during conflictual and non conflictual stimuli, in those with gambling, low‐frequency activity increased significantly more during conflictual than during non conflictual stimuli. The specific low‐frequency oscillatory pattern recorded in patients with Parkinson's disease who gamble could reflect a subthalamic dysfunction that makes their decisional threshold highly sensitive to risky options. When parkinsonian patients process stimuli related to an economics task, low‐frequency subthalamic activity increases. This task‐related change suggests that the cognitive‐affective system that drives economics decisional processes includes the subthalamic nucleus. The specific subthalamic neuronal activity during conflictual decisions in patients with pathological gambling supports the idea that the subthalamic nucleus is involved in behavioral strategies and in the pathophysiology of gambling. © 2013 International Parkinson and Movement Disorder Society</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23554027</pmid><doi>10.1002/mds.25427</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Decision Making - physiology decision-making Deep Brain Stimulation Electrodes, Implanted Female Gambling - complications Gambling - physiopathology Gambling - psychology Humans local field potentials Male Membrane Potentials - physiology Middle Aged Movement disorders Parkinson Disease - complications Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson Disease - therapy Parkinson's disease pathological gambling Risk-Taking subthalamic nucleus Subthalamic Nucleus - physiopathology |
| title | Pathological gambling in Parkinson's disease: Subthalamic oscillations during economics decisions |
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