Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite
Objectives/Hypothesis Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an...
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| Veröffentlicht in: | The Laryngoscope 2013-11, Vol.123 (11), p.E17-E22 |
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| container_title | The Laryngoscope |
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| creator | Erdogmuş, Nagehan Cingi, Cemal Canaz, Funda Acikalin, Mustafa Gurbuz, Melek Kezban Kaya, Ercan Çakli, Hamdi Incesulu, Armagan Ozudogru, Erkan |
| description | Objectives/Hypothesis
Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an injectable implant, in combination with diced or block cartilage grafts, to test the efficacy of injectable calcium hydroxylapatite on the survival of diced or block cartilage grafts.
Study Design
Prospective, controlled, parallel group animal study.
Methods
Fourteen New Zealand white rabbits were used. Block cartilage and diced cartilage grafts, alone and in combination with injectable calcium hydroxylapatite, were placed subcutaneously in the rabbits' dorsal thoracolumbar region. On the 90th day following surgery, the graft areas were extracted immediately after the rabbits were sacrificed. Pathological examination was conducted on all specimens.
Results
The pathologic and histochemical findings were compared between groups. There was chronic inflammation observed in all of the groups. However, none of the groups had metaplastic bone formation or calcification. The group that received diced cartilage in combination with the injectable implant received the highest scores for peripheral chondrocyte proliferation, matrix collagen, elastic fiber, and proteoglycan content (P |
| doi_str_mv | 10.1002/lary.24116 |
| format | Article |
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Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an injectable implant, in combination with diced or block cartilage grafts, to test the efficacy of injectable calcium hydroxylapatite on the survival of diced or block cartilage grafts.
Study Design
Prospective, controlled, parallel group animal study.
Methods
Fourteen New Zealand white rabbits were used. Block cartilage and diced cartilage grafts, alone and in combination with injectable calcium hydroxylapatite, were placed subcutaneously in the rabbits' dorsal thoracolumbar region. On the 90th day following surgery, the graft areas were extracted immediately after the rabbits were sacrificed. Pathological examination was conducted on all specimens.
Results
The pathologic and histochemical findings were compared between groups. There was chronic inflammation observed in all of the groups. However, none of the groups had metaplastic bone formation or calcification. The group that received diced cartilage in combination with the injectable implant received the highest scores for peripheral chondrocyte proliferation, matrix collagen, elastic fiber, and proteoglycan content (P <0.05). A comparison of the block and diced cartilage grafts revealed that peripheral chondrocyte proliferation was more pronounced in the diced cartilage grafts (P <0.05).
Conclusion
The use of calcium hydroxylapatite in combination with diced cartilage grafts does not have any long‐term negative effects on chondrocyte viability.
Level of Evidence
N/A. Laryngoscope, 123:E17–E22, 2013</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.24116</identifier><identifier>PMID: 23670605</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Biocompatible Materials - administration & dosage ; Calcium ; Cartilage - transplantation ; cartilage graft ; diced cartilage ; Durapatite - administration & dosage ; Graft Survival ; Hydroxyapatite ; Injectable calcium hydroxylapatite ; Injections ; Nasal Cartilages - surgery ; Rabbits ; rhinoplasty ; Tissue Transplantation - methods</subject><ispartof>The Laryngoscope, 2013-11, Vol.123 (11), p.E17-E22</ispartof><rights>Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3956-4af0812598a19eb6b9aa595742afdca17420c2a2e148d748602bd292ec86cee23</citedby><cites>FETCH-LOGICAL-c3956-4af0812598a19eb6b9aa595742afdca17420c2a2e148d748602bd292ec86cee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.24116$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.24116$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23670605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdogmuş, Nagehan</creatorcontrib><creatorcontrib>Cingi, Cemal</creatorcontrib><creatorcontrib>Canaz, Funda</creatorcontrib><creatorcontrib>Acikalin, Mustafa</creatorcontrib><creatorcontrib>Gurbuz, Melek Kezban</creatorcontrib><creatorcontrib>Kaya, Ercan</creatorcontrib><creatorcontrib>Çakli, Hamdi</creatorcontrib><creatorcontrib>Incesulu, Armagan</creatorcontrib><creatorcontrib>Ozudogru, Erkan</creatorcontrib><title>Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an injectable implant, in combination with diced or block cartilage grafts, to test the efficacy of injectable calcium hydroxylapatite on the survival of diced or block cartilage grafts.
Study Design
Prospective, controlled, parallel group animal study.
Methods
Fourteen New Zealand white rabbits were used. Block cartilage and diced cartilage grafts, alone and in combination with injectable calcium hydroxylapatite, were placed subcutaneously in the rabbits' dorsal thoracolumbar region. On the 90th day following surgery, the graft areas were extracted immediately after the rabbits were sacrificed. Pathological examination was conducted on all specimens.
Results
The pathologic and histochemical findings were compared between groups. There was chronic inflammation observed in all of the groups. However, none of the groups had metaplastic bone formation or calcification. The group that received diced cartilage in combination with the injectable implant received the highest scores for peripheral chondrocyte proliferation, matrix collagen, elastic fiber, and proteoglycan content (P <0.05). A comparison of the block and diced cartilage grafts revealed that peripheral chondrocyte proliferation was more pronounced in the diced cartilage grafts (P <0.05).
Conclusion
The use of calcium hydroxylapatite in combination with diced cartilage grafts does not have any long‐term negative effects on chondrocyte viability.
Level of Evidence
N/A. Laryngoscope, 123:E17–E22, 2013</description><subject>Animals</subject><subject>Biocompatible Materials - administration & dosage</subject><subject>Calcium</subject><subject>Cartilage - transplantation</subject><subject>cartilage graft</subject><subject>diced cartilage</subject><subject>Durapatite - administration & dosage</subject><subject>Graft Survival</subject><subject>Hydroxyapatite</subject><subject>Injectable calcium hydroxylapatite</subject><subject>Injections</subject><subject>Nasal Cartilages - surgery</subject><subject>Rabbits</subject><subject>rhinoplasty</subject><subject>Tissue Transplantation - methods</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E9vFCEYBnBiNHZbvfgBDIkX02QqMMAwx6axf5KJJrpGPZF3GKZlywxbmGm7375st-3BgycI_N4nbx6EPlByRAlhXzzEzRHjlMpXaEFFSQte1-I1WuTPslCC_dlD-ymtCKFVKchbtMdKWRFJxAKZn3O8dbfgcehx54ztMIwdbn0w19hAnJyHS4svI_RTwm7EJgytG2FyYcR3brrKbytrJmi9zd4bNw_4atPFcL_xsM5usu_Qmx58su-fzgP06_Tr8uS8aL6fXZwcN4UpayELDj1RlIlaAa1tK9saQNSi4gz6zgDNF2IYMEu56iquJGFtx2pmjZLGWlYeoM-73HUMN7NNkx5cMtZ7GG2Yk6acV5RISrb00z90FeY45u2yqhihqlQqq8OdMjGkFG2v19ENuW1Nid5Wr7fV68fqM_74FDm3g-1e6HPXGdAduHPebv4TpZvjH3-fQ4vdjEuTvX-ZgXitZVVWQv_-dqaXgjZLfsp1Uz4AQJ2d8Q</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Erdogmuş, Nagehan</creator><creator>Cingi, Cemal</creator><creator>Canaz, Funda</creator><creator>Acikalin, Mustafa</creator><creator>Gurbuz, Melek Kezban</creator><creator>Kaya, Ercan</creator><creator>Çakli, Hamdi</creator><creator>Incesulu, Armagan</creator><creator>Ozudogru, Erkan</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite</title><author>Erdogmuş, Nagehan ; Cingi, Cemal ; Canaz, Funda ; Acikalin, Mustafa ; Gurbuz, Melek Kezban ; Kaya, Ercan ; Çakli, Hamdi ; Incesulu, Armagan ; Ozudogru, Erkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3956-4af0812598a19eb6b9aa595742afdca17420c2a2e148d748602bd292ec86cee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biocompatible Materials - administration & dosage</topic><topic>Calcium</topic><topic>Cartilage - transplantation</topic><topic>cartilage graft</topic><topic>diced cartilage</topic><topic>Durapatite - administration & dosage</topic><topic>Graft Survival</topic><topic>Hydroxyapatite</topic><topic>Injectable calcium hydroxylapatite</topic><topic>Injections</topic><topic>Nasal Cartilages - surgery</topic><topic>Rabbits</topic><topic>rhinoplasty</topic><topic>Tissue Transplantation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erdogmuş, Nagehan</creatorcontrib><creatorcontrib>Cingi, Cemal</creatorcontrib><creatorcontrib>Canaz, Funda</creatorcontrib><creatorcontrib>Acikalin, Mustafa</creatorcontrib><creatorcontrib>Gurbuz, Melek Kezban</creatorcontrib><creatorcontrib>Kaya, Ercan</creatorcontrib><creatorcontrib>Çakli, Hamdi</creatorcontrib><creatorcontrib>Incesulu, Armagan</creatorcontrib><creatorcontrib>Ozudogru, Erkan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erdogmuş, Nagehan</au><au>Cingi, Cemal</au><au>Canaz, Funda</au><au>Acikalin, Mustafa</au><au>Gurbuz, Melek Kezban</au><au>Kaya, Ercan</au><au>Çakli, Hamdi</au><au>Incesulu, Armagan</au><au>Ozudogru, Erkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2013-11</date><risdate>2013</risdate><volume>123</volume><issue>11</issue><spage>E17</spage><epage>E22</epage><pages>E17-E22</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Dorsal nasal irregularities after trauma, and various procedures such as excessive nasal hump resection, are major problems for patients who have undergone rhinoplasty. Many grafts have been described for the correction of dorsal nasal irregularities. In this study, we used an injectable implant, in combination with diced or block cartilage grafts, to test the efficacy of injectable calcium hydroxylapatite on the survival of diced or block cartilage grafts.
Study Design
Prospective, controlled, parallel group animal study.
Methods
Fourteen New Zealand white rabbits were used. Block cartilage and diced cartilage grafts, alone and in combination with injectable calcium hydroxylapatite, were placed subcutaneously in the rabbits' dorsal thoracolumbar region. On the 90th day following surgery, the graft areas were extracted immediately after the rabbits were sacrificed. Pathological examination was conducted on all specimens.
Results
The pathologic and histochemical findings were compared between groups. There was chronic inflammation observed in all of the groups. However, none of the groups had metaplastic bone formation or calcification. The group that received diced cartilage in combination with the injectable implant received the highest scores for peripheral chondrocyte proliferation, matrix collagen, elastic fiber, and proteoglycan content (P <0.05). A comparison of the block and diced cartilage grafts revealed that peripheral chondrocyte proliferation was more pronounced in the diced cartilage grafts (P <0.05).
Conclusion
The use of calcium hydroxylapatite in combination with diced cartilage grafts does not have any long‐term negative effects on chondrocyte viability.
Level of Evidence
N/A. Laryngoscope, 123:E17–E22, 2013</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23670605</pmid><doi>10.1002/lary.24116</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Laryngoscope, 2013-11, Vol.123 (11), p.E17-E22 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biocompatible Materials - administration & dosage Calcium Cartilage - transplantation cartilage graft diced cartilage Durapatite - administration & dosage Graft Survival Hydroxyapatite Injectable calcium hydroxylapatite Injections Nasal Cartilages - surgery Rabbits rhinoplasty Tissue Transplantation - methods |
| title | Survival of diced and block cartilage grafts in combination with injectable calcium hydroxylapatite |
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