A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser
Objectives/Hypothesis Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to dri...
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| Veröffentlicht in: | The Laryngoscope 2013-11, Vol.123 (11), p.2770-2775 |
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| container_title | The Laryngoscope |
| container_volume | 123 |
| creator | Böttcher, Arne Clauditz, Till S. Knecht, Rainald Kucher, Stanislav Wöllmer, Wolfgang Wilczak, Waldemar Krötz, Peter Jowett, Nathan Dalchow, Carsten V. Münscher, Adrian Miller, R. J. Dwayne |
| description | Objectives/Hypothesis
Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to drive ablation on timescales faster than energy transport to minimize collateral damage to adjacent cells.
Study Design
Animal cadaver study.
Methods
Cuts in porcine laryngeal epithelium, lamina propria, and cartilage were made using PIRL and carbon dioxide (CO2) laser. Lateral damage zones and cutting gaps were histologically compared.
Results
The mean widths of epithelial (8.5 μm), subepithelial (10.9 μm), and cartilage damage zones (8.1 μm) were significantly lower for cuts made by PIRL compared with CO2 laser (p < 0.001). Mean cutting gaps in vocal fold (174.7 μm) and epiglottic cartilage (56.3 μm) were significantly narrower for cuts made by PIRL compared with CO2 laser (P < 0.01, P < 0.05).
Conclusion
PIRL ablation demonstrates superiority over CO2 laser in cutting precision with less collateral tissue damage.
Level of Evidence
N/A. Laryngoscope, 123:2770–2775, 2013 |
| doi_str_mv | 10.1002/lary.24124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1447105432</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1447105432</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3954-8a322a4e37cc52503374abbefeb6b70d5b3503aa0bc81f921ab4b568ba8e0acf3</originalsourceid><addsrcrecordid>eNp9kE1PGzEQhi1UBClw6Q-oLPVSIS34c73bWxTxJSJACAScLNuZpUuddWrvts2_xyHAoQdOc5jnfTTzIvSFkgNKCDv0Ji4PmKBMbKARlZwWoq7lJzTKS15Ukt1vo88pPRFCFZdkC20zXipS8nqE7sa4C3_A4z4Ej9sOr2TdIxiP0xAfIS5_4KsIvp23Xd7gCGnwfcKhwf1PwIvWhQQudLOcbaKJMMuGBHEXbTbGJ9h7nTvo9vjoZnJaTC9PzibjaeF4LUVRGc6YEcCVc5JJwrkSxlpowJZWkZm0-WBuDLGuok3NqLHCyrKypgJiXMN30Pe1dxHD7wFSr-dtcuC96SAMSVMhFCVScJbRb_-hT2GIXb4uU4oRWglBMrW_plwMKUVo9CK28_y6pkSv6tarhvRL3Rn--qoc7Bxm7-hbvxmga-Bv62H5gUpPx9cPb9JinWlTD__eMyb-0qXiSuq7ixM9Yef8-Gp6oSl_Bu-6mdk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1472018440</pqid></control><display><type>article</type><title>A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Böttcher, Arne ; Clauditz, Till S. ; Knecht, Rainald ; Kucher, Stanislav ; Wöllmer, Wolfgang ; Wilczak, Waldemar ; Krötz, Peter ; Jowett, Nathan ; Dalchow, Carsten V. ; Münscher, Adrian ; Miller, R. J. Dwayne</creator><creatorcontrib>Böttcher, Arne ; Clauditz, Till S. ; Knecht, Rainald ; Kucher, Stanislav ; Wöllmer, Wolfgang ; Wilczak, Waldemar ; Krötz, Peter ; Jowett, Nathan ; Dalchow, Carsten V. ; Münscher, Adrian ; Miller, R. J. Dwayne</creatorcontrib><description>Objectives/Hypothesis
Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to drive ablation on timescales faster than energy transport to minimize collateral damage to adjacent cells.
Study Design
Animal cadaver study.
Methods
Cuts in porcine laryngeal epithelium, lamina propria, and cartilage were made using PIRL and carbon dioxide (CO2) laser. Lateral damage zones and cutting gaps were histologically compared.
Results
The mean widths of epithelial (8.5 μm), subepithelial (10.9 μm), and cartilage damage zones (8.1 μm) were significantly lower for cuts made by PIRL compared with CO2 laser (p < 0.001). Mean cutting gaps in vocal fold (174.7 μm) and epiglottic cartilage (56.3 μm) were significantly narrower for cuts made by PIRL compared with CO2 laser (P < 0.01, P < 0.05).
Conclusion
PIRL ablation demonstrates superiority over CO2 laser in cutting precision with less collateral tissue damage.
Level of Evidence
N/A. Laryngoscope, 123:2770–2775, 2013</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.24124</identifier><identifier>PMID: 23670639</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; CO2 ; damage zone ; histology ; Infrared Rays - therapeutic use ; laryngeal surgery ; Laryngectomy - methods ; Larynx surgery ; laser ; Laser Therapy - methods ; Lasers, Gas - therapeutic use ; PIRL ; Swine</subject><ispartof>The Laryngoscope, 2013-11, Vol.123 (11), p.2770-2775</ispartof><rights>Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3954-8a322a4e37cc52503374abbefeb6b70d5b3503aa0bc81f921ab4b568ba8e0acf3</citedby><cites>FETCH-LOGICAL-c3954-8a322a4e37cc52503374abbefeb6b70d5b3503aa0bc81f921ab4b568ba8e0acf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.24124$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.24124$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23670639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Böttcher, Arne</creatorcontrib><creatorcontrib>Clauditz, Till S.</creatorcontrib><creatorcontrib>Knecht, Rainald</creatorcontrib><creatorcontrib>Kucher, Stanislav</creatorcontrib><creatorcontrib>Wöllmer, Wolfgang</creatorcontrib><creatorcontrib>Wilczak, Waldemar</creatorcontrib><creatorcontrib>Krötz, Peter</creatorcontrib><creatorcontrib>Jowett, Nathan</creatorcontrib><creatorcontrib>Dalchow, Carsten V.</creatorcontrib><creatorcontrib>Münscher, Adrian</creatorcontrib><creatorcontrib>Miller, R. J. Dwayne</creatorcontrib><title>A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to drive ablation on timescales faster than energy transport to minimize collateral damage to adjacent cells.
Study Design
Animal cadaver study.
Methods
Cuts in porcine laryngeal epithelium, lamina propria, and cartilage were made using PIRL and carbon dioxide (CO2) laser. Lateral damage zones and cutting gaps were histologically compared.
Results
The mean widths of epithelial (8.5 μm), subepithelial (10.9 μm), and cartilage damage zones (8.1 μm) were significantly lower for cuts made by PIRL compared with CO2 laser (p < 0.001). Mean cutting gaps in vocal fold (174.7 μm) and epiglottic cartilage (56.3 μm) were significantly narrower for cuts made by PIRL compared with CO2 laser (P < 0.01, P < 0.05).
Conclusion
PIRL ablation demonstrates superiority over CO2 laser in cutting precision with less collateral tissue damage.
Level of Evidence
N/A. Laryngoscope, 123:2770–2775, 2013</description><subject>Animals</subject><subject>CO2</subject><subject>damage zone</subject><subject>histology</subject><subject>Infrared Rays - therapeutic use</subject><subject>laryngeal surgery</subject><subject>Laryngectomy - methods</subject><subject>Larynx surgery</subject><subject>laser</subject><subject>Laser Therapy - methods</subject><subject>Lasers, Gas - therapeutic use</subject><subject>PIRL</subject><subject>Swine</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhi1UBClw6Q-oLPVSIS34c73bWxTxJSJACAScLNuZpUuddWrvts2_xyHAoQdOc5jnfTTzIvSFkgNKCDv0Ji4PmKBMbKARlZwWoq7lJzTKS15Ukt1vo88pPRFCFZdkC20zXipS8nqE7sa4C3_A4z4Ej9sOr2TdIxiP0xAfIS5_4KsIvp23Xd7gCGnwfcKhwf1PwIvWhQQudLOcbaKJMMuGBHEXbTbGJ9h7nTvo9vjoZnJaTC9PzibjaeF4LUVRGc6YEcCVc5JJwrkSxlpowJZWkZm0-WBuDLGuok3NqLHCyrKypgJiXMN30Pe1dxHD7wFSr-dtcuC96SAMSVMhFCVScJbRb_-hT2GIXb4uU4oRWglBMrW_plwMKUVo9CK28_y6pkSv6tarhvRL3Rn--qoc7Bxm7-hbvxmga-Bv62H5gUpPx9cPb9JinWlTD__eMyb-0qXiSuq7ixM9Yef8-Gp6oSl_Bu-6mdk</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Böttcher, Arne</creator><creator>Clauditz, Till S.</creator><creator>Knecht, Rainald</creator><creator>Kucher, Stanislav</creator><creator>Wöllmer, Wolfgang</creator><creator>Wilczak, Waldemar</creator><creator>Krötz, Peter</creator><creator>Jowett, Nathan</creator><creator>Dalchow, Carsten V.</creator><creator>Münscher, Adrian</creator><creator>Miller, R. J. Dwayne</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser</title><author>Böttcher, Arne ; Clauditz, Till S. ; Knecht, Rainald ; Kucher, Stanislav ; Wöllmer, Wolfgang ; Wilczak, Waldemar ; Krötz, Peter ; Jowett, Nathan ; Dalchow, Carsten V. ; Münscher, Adrian ; Miller, R. J. Dwayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3954-8a322a4e37cc52503374abbefeb6b70d5b3503aa0bc81f921ab4b568ba8e0acf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>CO2</topic><topic>damage zone</topic><topic>histology</topic><topic>Infrared Rays - therapeutic use</topic><topic>laryngeal surgery</topic><topic>Laryngectomy - methods</topic><topic>Larynx surgery</topic><topic>laser</topic><topic>Laser Therapy - methods</topic><topic>Lasers, Gas - therapeutic use</topic><topic>PIRL</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Böttcher, Arne</creatorcontrib><creatorcontrib>Clauditz, Till S.</creatorcontrib><creatorcontrib>Knecht, Rainald</creatorcontrib><creatorcontrib>Kucher, Stanislav</creatorcontrib><creatorcontrib>Wöllmer, Wolfgang</creatorcontrib><creatorcontrib>Wilczak, Waldemar</creatorcontrib><creatorcontrib>Krötz, Peter</creatorcontrib><creatorcontrib>Jowett, Nathan</creatorcontrib><creatorcontrib>Dalchow, Carsten V.</creatorcontrib><creatorcontrib>Münscher, Adrian</creatorcontrib><creatorcontrib>Miller, R. J. Dwayne</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Böttcher, Arne</au><au>Clauditz, Till S.</au><au>Knecht, Rainald</au><au>Kucher, Stanislav</au><au>Wöllmer, Wolfgang</au><au>Wilczak, Waldemar</au><au>Krötz, Peter</au><au>Jowett, Nathan</au><au>Dalchow, Carsten V.</au><au>Münscher, Adrian</au><au>Miller, R. J. Dwayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2013-11</date><risdate>2013</risdate><volume>123</volume><issue>11</issue><spage>2770</spage><epage>2775</epage><pages>2770-2775</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Conventional lasers ablate tissue through photothermal, photomechanical, and/or photoionizing effects, which may result in collateral tissue damage. The novel nonionizing picosecond infrared laser (PIRL) selectively energizes tissue water molecules using ultrafast pulses to drive ablation on timescales faster than energy transport to minimize collateral damage to adjacent cells.
Study Design
Animal cadaver study.
Methods
Cuts in porcine laryngeal epithelium, lamina propria, and cartilage were made using PIRL and carbon dioxide (CO2) laser. Lateral damage zones and cutting gaps were histologically compared.
Results
The mean widths of epithelial (8.5 μm), subepithelial (10.9 μm), and cartilage damage zones (8.1 μm) were significantly lower for cuts made by PIRL compared with CO2 laser (p < 0.001). Mean cutting gaps in vocal fold (174.7 μm) and epiglottic cartilage (56.3 μm) were significantly narrower for cuts made by PIRL compared with CO2 laser (P < 0.01, P < 0.05).
Conclusion
PIRL ablation demonstrates superiority over CO2 laser in cutting precision with less collateral tissue damage.
Level of Evidence
N/A. Laryngoscope, 123:2770–2775, 2013</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23670639</pmid><doi>10.1002/lary.24124</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2013-11, Vol.123 (11), p.2770-2775 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals CO2 damage zone histology Infrared Rays - therapeutic use laryngeal surgery Laryngectomy - methods Larynx surgery laser Laser Therapy - methods Lasers, Gas - therapeutic use PIRL Swine |
| title | A novel tool in laryngeal surgery: Preliminary results of the picosecond infrared laser |
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