Coenzyme Q10 deficiency in children: Frequent type 2C muscle fibers with normal morphology

ABSTRACT Introduction: Neurological disorders with low tissue coenzyme Q10 (CoQ10) levels are important to identify, as they may be treatable. Methods: We evaluated retrospectively clinical, laboratory, and muscle histochemistry and oxidative enzyme characteristics in 49 children with suspected mito...

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Veröffentlicht in:	Muscle & nerve 2013-11, Vol.48 (5), p.722-726
Hauptverfasser:	Sommerville, R. Brian, Zaidman, Craig M., Pestronk, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - diagnosis Abnormalities, Multiple - enzymology Abnormalities, Multiple - pathology Ataxia - diagnosis Ataxia - enzymology Ataxia - pathology Child Child, Preschool coenzyme Q10 deficiency developmental delay Enzymes Female Humans Incidence Infant Male Mitochondrial Diseases - diagnosis Mitochondrial Diseases - enzymology Mitochondrial Diseases - pathology mitochondrial disorders Muscle Fibers, Fast-Twitch - cytology Muscle Fibers, Fast-Twitch - enzymology Muscle Fibers, Fast-Twitch - pathology muscle pathology Muscle Weakness - diagnosis Muscle Weakness - enzymology Muscle Weakness - pathology pediatric neurology Quadriceps Muscle - enzymology Quadriceps Muscle - pathology Retrospective Studies Sensitivity and Specificity type 2C fibers Ubiquinone - analogs & derivatives Ubiquinone - biosynthesis Ubiquinone - deficiency
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