Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain

The transient receptor potential channel A1 (TRPA1) is unique among ion channels of higher vertebrates in that it harbors a large ankyrin repeat domain. The TRPA1 channel is expressed in the inner ear and in nociceptive neurons. It is involved in hearing as well as in the perception of pungent and i...

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Veröffentlicht in:	Journal of molecular modeling 2013-11, Vol.19 (11), p.4689-4700
Hauptverfasser:	Zayats, Vasilina, Samad, Abdul, Minofar, Babak, Roelofs, Katherine E., Stockner, Thomas, Ettrich, Rudiger
Format:	Artikel
Sprache:	eng
Schlagworte:	Ankyrin Repeat - physiology Binding Sites Calcium - metabolism Calcium Channels - chemistry Calcium Channels - physiology Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Computer Appl. in Life Sciences Computer Applications in Chemistry EF Hand Motifs - physiology Humans Models, Molecular Molecular Dynamics Simulation Molecular Medicine Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - physiology Original Paper Theoretical and Computational Chemistry Transient Receptor Potential Channels - chemistry Transient Receptor Potential Channels - physiology TRPA1 Cation Channel
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