Vascular Endothelial σ1-Receptor Stimulation With SA4503 Rescues Aortic Relaxation via Akt/eNOS Signaling in Ovariectomized Rats With Aortic Banding

Background: We previously reported that σ1-receptor (σ1R) expression in the thoracic aorta decreased after pressure overload (PO) induced by abdominal aortic banding in ovariectomized (OVX) rats. Here, we asked whether stimulation of σ1R with the selective agonist SA4503 elicits functional recovery...

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Veröffentlicht in:	Circulation Journal 2013, Vol.77(11), pp.2831-2840
Hauptverfasser:	Tagashira, Hideaki, Matsumoto, Takayuki, Taguchi, Kumiko, Zhang, Chen, Han, Feng, Ishida, Keiko, Nemoto, Shingo, Kobayashi, Tsuneo, Fukunaga, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Agonists - pharmacology Animals Anisoles - pharmacology Antipsychotic Agents - pharmacology Aorta, Abdominal - injuries Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Aortic Diseases - metabolism Aortic Diseases - pathology Cyclic GMP - metabolism Endothelial nitric oxide synthase Endothelin-1 - pharmacology Endothelium, Vascular - injuries Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Nitric Oxide Synthase Type III - metabolism Nootropic Agents - pharmacology Ovariectomy Phenylephrine - pharmacology Phosphorylation - drug effects Piperazines - pharmacology Propylamines - pharmacology Proto-Oncogene Proteins c-akt - metabolism Rats, Wistar Receptors, sigma - agonists Receptors, sigma - metabolism Sigma-1 Receptor Vascular disease Vasodilation - drug effects σ1-receptor
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