Complement C5A Antagonist Treatment Improves the Acute Circulatory and Inflammatory Consequences of Experimental Cardiac Tamponade

OBJECTIVE:Cardiogenic shock often leads to splanchnic macro- and microcirculatory complications, and these events are linked to local and systemic inflammatory activation. Our aim was to investigate the consequences of complement C5a antagonist treatment on the early circulatory and inflammatory cha...

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Veröffentlicht in:	Critical care medicine 2013-11, Vol.41 (11), p.e344-e351
Hauptverfasser:	Érces, Dániel, Nógrády, Miklós, Nagy, Enikő, Varga, Gabriella, Vass, Andrea, Süveges, Gábor, Imai, Masaki, Okada, Noriko, Okada, Hidechika, Boros, Mihály, Kaszaki, József
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiac Tamponade - physiopathology Cardiac Tamponade - therapy Complement C5a - antagonists & inhibitors Disease Models, Animal Endothelin-1 - metabolism Female Hemodynamics Histamine - blood HMGB1 Protein - metabolism Intestinal Mucosa - blood supply Male Microcirculation Peptides - pharmacology Random Allocation Superoxides - metabolism Swine
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