Cloning and characterization of the retinoic acid receptor-like protein in the rock shell, Thais clavigera

•We examined the mechanism of imposex induction, focusing on RXR signaling pathway.•To investigate candidate partner for RXR, we isolated an RAR-like cDNA in rockshell.•This RAR-like protein was not activated by retinoic acids.•However, it may form a heterodimer with TcRXR isoforms. The organotin co...

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Veröffentlicht in:	Aquatic toxicology 2013-10, Vol.142-143, p.403-413
Hauptverfasser:	Urushitani, Hiroshi, Katsu, Yoshinao, Ohta, Yasuhiko, Shiraishi, Hiroaki, Iguchi, Taisen, Horiguchi, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cloning, Molecular complementary DNA Gastropoda Gastropoda - drug effects Gastropoda - genetics Gene Expression Regulation - drug effects genes humans Imposex organotin compounds proteins Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Reporter gene assay retinoic acid Retinoic acid receptor (RAR) Retinoid X receptor (RXR) Rock shell sex differentiation disorders Thais clavigera transcription (genetics) transcription factors transcriptional activation Tretinoin - pharmacology vitamin A
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