Volumetric erythrocyte macrocytosis induced by hydroxyurea
An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell...
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| Veröffentlicht in: | American journal of clinical pathology 1986-03, Vol.85 (3), p.337-341 |
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| container_title | American journal of clinical pathology |
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| creator | BURNS, E. R REED, L. J WENZ, B |
| description | An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. The cell has many characteristics in common with the red blood cells of neonates. Volumetric macrocytosis accompanies sustained hydroxyurea therapy and may represent a drug-induced dyserythropoiesis. |
| doi_str_mv | 10.1093/ajcp/85.3.337 |
| format | Article |
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R ; REED, L. J ; WENZ, B</creator><creatorcontrib>BURNS, E. R ; REED, L. J ; WENZ, B</creatorcontrib><description>An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. The cell has many characteristics in common with the red blood cells of neonates. Volumetric macrocytosis accompanies sustained hydroxyurea therapy and may represent a drug-induced dyserythropoiesis.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/85.3.337</identifier><identifier>PMID: 3790210</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Biological and medical sciences ; Blood Viscosity - drug effects ; Drug toxicity and drugs side effects treatment ; Erythrocyte Deformability - drug effects ; Erythrocyte Indices - drug effects ; Erythrocytes, Abnormal - drug effects ; Erythrocytes, Abnormal - ultrastructure ; Humans ; Hydroxyurea - adverse effects ; Hydroxyurea - therapeutic use ; Medical sciences ; Microscopy, Electron, Scanning ; Pharmacology. 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J</creatorcontrib><creatorcontrib>WENZ, B</creatorcontrib><title>Volumetric erythrocyte macrocytosis induced by hydroxyurea</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. The cell has many characteristics in common with the red blood cells of neonates. Volumetric macrocytosis accompanies sustained hydroxyurea therapy and may represent a drug-induced dyserythropoiesis.</description><subject>Biological and medical sciences</subject><subject>Blood Viscosity - drug effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Erythrocyte Deformability - drug effects</subject><subject>Erythrocyte Indices - drug effects</subject><subject>Erythrocytes, Abnormal - drug effects</subject><subject>Erythrocytes, Abnormal - ultrastructure</subject><subject>Humans</subject><subject>Hydroxyurea - adverse effects</subject><subject>Hydroxyurea - therapeutic use</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: blood</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhhdRaq0ePQo5iLek-5XsjjcpfkHBi3pdNrsbmpI0dTcB8-_d2tDTDPM-DDMPQrcEZwQDW-qt2S9lnrGMMXGG5gQ4S4Wg9BzNMcY0BSLYJboKYYsxoRLzGZoxAZgSPEeP310ztK73tUmcH_uN78zYu6TV5r_rQh2SemcH42xSjslmtL77HQfv9DW6qHQT3M1UF-jr5flz9ZauP17fV0_r1HDC-1RAXmliTGHy0lLQwApOJQVusaEaChopQYDKSjOwcUqtyMtKYpvHJziwBXo47t377mdwoVdtHYxrGr1z3RAU4byQRU4imB7BeHoI3lVq7-tW-1ERrA6u1MGVkrliKrqK_N20eChbZ0_0JCfm91Oug9FN5fXO1OGECeBSAGN_SfxxqQ</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>BURNS, E. R</creator><creator>REED, L. 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Drug treatments</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURNS, E. R</creatorcontrib><creatorcontrib>REED, L. J</creatorcontrib><creatorcontrib>WENZ, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURNS, E. R</au><au>REED, L. J</au><au>WENZ, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Volumetric erythrocyte macrocytosis induced by hydroxyurea</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>85</volume><issue>3</issue><spage>337</spage><epage>341</epage><pages>337-341</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. 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| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1986-03, Vol.85 (3), p.337-341 |
| issn | 0002-9173 1943-7722 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Biological and medical sciences Blood Viscosity - drug effects Drug toxicity and drugs side effects treatment Erythrocyte Deformability - drug effects Erythrocyte Indices - drug effects Erythrocytes, Abnormal - drug effects Erythrocytes, Abnormal - ultrastructure Humans Hydroxyurea - adverse effects Hydroxyurea - therapeutic use Medical sciences Microscopy, Electron, Scanning Pharmacology. Drug treatments Toxicity: blood |
| title | Volumetric erythrocyte macrocytosis induced by hydroxyurea |
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