Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, B+ tenascin-C and ED-A+ fibronectin in dilated cardiomyopathy: Potential impact on disease progression and patients' prognosis

Abstract Background Dilated cardiomyopathy (DCM) is associated with heart failure and increased mortality and there is no reliable biomarker to estimate patients' prognosis. During cardiac remodeling, an extensive reorganization of the extracellular matrix occurs. The study was aimed to investi...

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Veröffentlicht in:	International journal of cardiology 2013-10, Vol.168 (6), p.5344-5351
Hauptverfasser:	Franz, Marcus, Berndt, Alexander, Neri, Dario, Galler, Kerstin, Grün, Katja, Porrmann, Christiane, Reinbothe, Franziska, Mall, Gerhard, Schlattmann, Peter, Renner, André, Figulla, Hans Reiner, Jung, Christian, Küthe, Friedhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarkers - blood Biomarkers - metabolism Biopsy Cardiology. Vascular system Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - pathology Cardiovascular Dilated cardiomyopathy Disease Progression Extracellular Matrix - metabolism Female Fibronectin Fibronectins - blood Fibronectins - metabolism Fibrosis - metabolism Fibrosis - pathology Fluorescent Antibody Technique Heart Humans Male Matrix Metalloproteinase 9 - blood Matrix Metalloproteinase 9 - metabolism Medical sciences Middle Aged MMP-9 Myocarditis. Cardiomyopathies Myocardium - metabolism Myocardium - pathology Prognosis Risk Factors Tenascin - blood Tenascin - metabolism Tenascin-C TIMP-1 Tissue Inhibitor of Metalloproteinase-1 - blood Tissue Inhibitor of Metalloproteinase-1 - metabolism Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - mortality Ventricular Dysfunction, Left - pathology
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