IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells

Chronic lymphocytic leukemia (CLL) cells multiply in secondary lymphoid tissue, but the mechanisms leading to their proliferation are still uncertain. In addition to B-cell receptor (BCR)–triggered signals, other microenvironmental factors might well be involved. In proliferation centers, leukemic B...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2013-10, Vol.122 (17), p.3010-3019
Hauptverfasser:	Pascutti, Maria Fernanda, Jak, Margot, Tromp, Jacqueline M., Derks, Ingrid A.M., Remmerswaal, Ester B.M., Thijssen, Rachel, van Attekum, Martijn H.A., van Bochove, Gregor G., Luijks, Dieuwertje M., Pals, Steven T., van Lier, René A.W., Kater, Arnon P., van Oers, Marinus H.J., Eldering, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - immunology B-Lymphocytes - immunology B-Lymphocytes - pathology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD40 Antigens - genetics CD40 Antigens - immunology CD40 Ligand - genetics CD40 Ligand - immunology Cell Communication - immunology Gene Expression Profiling Gene Expression Regulation Humans Interleukins - genetics Interleukins - immunology Janus Kinases - genetics Janus Kinases - immunology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation Primary Cell Culture Receptors, Antigen, B-Cell - genetics Receptors, Antigen, B-Cell - immunology Signal Transduction T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!