Valproate increases diazepam impregnation selectively in CNS of the rat after subchronic administration

Valproate-Diazepam association is not unusual in the treatment of epilepsies. The present paper investigates in an experimental study the effect of sodium valproate (VPA) on the regional cerebral level of diazepam (DZP), and the relationship with plasma or erythrocytes amounts after subchronic admin...

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Veröffentlicht in:	Life sciences (1973) 1985-10, Vol.37 (14), p.1343-1349
Hauptverfasser:	Hariton, C., Jadot, G., Mesdjian, E., Cano, J-P., Mandel, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Applied sciences Biological and medical sciences Blood Proteins - metabolism Brain - drug effects Brain - metabolism Cerebellum - metabolism Diazepam - administration & dosage Diazepam - blood Diazepam - metabolism Drug Interactions Erythrocytes - metabolism Exact sciences and technology Hippocampus - metabolism Male Medical sciences Medulla Oblongata - metabolism Neuropharmacology Other techniques and industries Pharmacology. Drug treatments Pons - metabolism Protein Binding Rats Rats, Inbred Strains Tissue Distribution Valproic Acid - administration & dosage Valproic Acid - blood Valproic Acid - pharmacology
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