Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

Greatwall is a protein kinase involved in the inhibition of protein phosphatase 2 (PP2A)-B55 complexes to maintain the mitotic state. Although its biochemical activity has been deeply characterized in Xenopus, its specific relevance during the progression of mitosis is not fully understood. By using...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-10, Vol.110 (43), p.17374-17379
Hauptverfasser:	Álvarez-Fernández, Mónica, Sánchez-Martínez, Ruth, Sanz-Castillo, Belén, Gan, Pei Pei, Sanz-Flores, María, Trakala, Marianna, Ruiz-Torres, Miguel, Lorca, Thierry, Castro, Anna, Malumbres, Marcos
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Amino Acid Sequence Animals Biological Sciences Cell cycle Cell Line, Tumor Cells Cells, Cultured chromosome morphology Chromosomes Cultured cells Cyclins Cytoplasm Embryo, Mammalian - cytology Embryo, Mammalian - embryology Embryo, Mammalian - metabolism embryogenesis Embryonic growth stage Embryos Female Humans Kinases knockout mutants Luminescent Proteins - genetics Luminescent Proteins - metabolism Male Mammals Mammals - embryology Mammals - genetics Mammals - metabolism Mice Mice, Knockout Microscopy, Fluorescence Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitosis Nuclear Envelope - metabolism nuclear membrane Phosphatases Phosphorylation physiological transport Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism Protein Subunits - genetics Protein Subunits - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA Interference Rodents Sequence Homology, Amino Acid Time Factors Xenopus
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