Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors
Mycelia of cultured Cordyceps sinensis (CS) is one of the most common substitutes for natural CS and was approved for arrhythmia in China. However, the role of CS in ameliorating injury during ischemia‐reperfusion (I/R) is still unclear. We examined effects of extracts from CS on I/R and investigate...
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description | Mycelia of cultured Cordyceps sinensis (CS) is one of the most common substitutes for natural CS and was approved for arrhythmia in China. However, the role of CS in ameliorating injury during ischemia‐reperfusion (I/R) is still unclear. We examined effects of extracts from CS on I/R and investigated the possible mechanisms. Post‐ischemic coronary perfusion pressure, ventricular function, and coronary flow were measured using the Langendorff mouse heart model. Oxidative stress of cardiac homogenates was performed using an ELISA. Our results indicate that CS affords cardioprotection possibly through enhanced adenosine receptor activation. Cardioprotection was demonstrated by reduced post‐ischemic diastolic dysfunction and improved recovery of pressure development and coronary flow. Treatment with CS largely abrogates oxidative stress and damage in glucose‐ or pyruvate‐perfused hearts. Importantly, observed reductions in oxidative stress [glutathione disulfide (GSSG)]/[GSSG + glutathione] and [malondialdehyde (MDA)]/[superoxide dismutase + MDA] ratios as well as the resultant damage upon CS treatment correlate with functional markers of post‐ischemic myocardial outcome. These effects of CS were partially blocked by 8‐ρ‐sulfophenyltheophylline, an adenosine receptor antagonist. Our results demonstrate a suppressive role of CS in ischemic contracture. Meanwhile, the results also suggest pre‐ischemic adenosine receptor activation may be involved in reducing contracture in hearts pretreated with CS. Copyright © 2012 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/ptr.4899 |
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However, the role of CS in ameliorating injury during ischemia‐reperfusion (I/R) is still unclear. We examined effects of extracts from CS on I/R and investigated the possible mechanisms. Post‐ischemic coronary perfusion pressure, ventricular function, and coronary flow were measured using the Langendorff mouse heart model. Oxidative stress of cardiac homogenates was performed using an ELISA. Our results indicate that CS affords cardioprotection possibly through enhanced adenosine receptor activation. Cardioprotection was demonstrated by reduced post‐ischemic diastolic dysfunction and improved recovery of pressure development and coronary flow. Treatment with CS largely abrogates oxidative stress and damage in glucose‐ or pyruvate‐perfused hearts. Importantly, observed reductions in oxidative stress [glutathione disulfide (GSSG)]/[GSSG + glutathione] and [malondialdehyde (MDA)]/[superoxide dismutase + MDA] ratios as well as the resultant damage upon CS treatment correlate with functional markers of post‐ischemic myocardial outcome. These effects of CS were partially blocked by 8‐ρ‐sulfophenyltheophylline, an adenosine receptor antagonist. Our results demonstrate a suppressive role of CS in ischemic contracture. Meanwhile, the results also suggest pre‐ischemic adenosine receptor activation may be involved in reducing contracture in hearts pretreated with CS. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4899</identifier><identifier>PMID: 23192916</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adenosine ; adenosine receptor ; Animals ; antioxidant stress ; Antioxidants - pharmacology ; Cardiology ; Cardiotonic Agents - pharmacology ; Cordyceps - chemistry ; Cordyceps sinensis ; Glutathione - metabolism ; Glutathione Disulfide - metabolism ; Heart ; Heart - drug effects ; Heart - physiopathology ; In Vitro Techniques ; ischemia-reperfusion ; Male ; Malondialdehyde - metabolism ; Mice ; Mice, Inbred C57BL ; Mycelium - chemistry ; Myocardium - metabolism ; Oxidation-Reduction ; Oxidative stress ; Oxidative Stress - drug effects ; Receptors, Purinergic P1 - metabolism ; Reperfusion Injury - drug therapy ; Rodents ; Superoxide Dismutase - metabolism ; Theophylline - analogs & derivatives ; Theophylline - pharmacology</subject><ispartof>Phytotherapy research, 2013-11, Vol.27 (11), p.1597-1604</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3029-15ccefe415dbeec79266c8560ffb611ddb4a2ad8fce556c4b7e5641442aee19c3</citedby><cites>FETCH-LOGICAL-c3029-15ccefe415dbeec79266c8560ffb611ddb4a2ad8fce556c4b7e5641442aee19c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4899$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4899$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23192916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Xiao-Feng</creatorcontrib><creatorcontrib>Zhang, Zhong-Miao</creatorcontrib><creatorcontrib>Yao, Hong-Yi</creatorcontrib><creatorcontrib>Guan, Yan</creatorcontrib><creatorcontrib>Zhu, Jian-Ping</creatorcontrib><creatorcontrib>Zhang, Lin-Hui</creatorcontrib><creatorcontrib>Jia, Yong-Liang</creatorcontrib><creatorcontrib>Wang, Ru-Wei</creatorcontrib><title>Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Mycelia of cultured Cordyceps sinensis (CS) is one of the most common substitutes for natural CS and was approved for arrhythmia in China. However, the role of CS in ameliorating injury during ischemia‐reperfusion (I/R) is still unclear. We examined effects of extracts from CS on I/R and investigated the possible mechanisms. Post‐ischemic coronary perfusion pressure, ventricular function, and coronary flow were measured using the Langendorff mouse heart model. Oxidative stress of cardiac homogenates was performed using an ELISA. Our results indicate that CS affords cardioprotection possibly through enhanced adenosine receptor activation. Cardioprotection was demonstrated by reduced post‐ischemic diastolic dysfunction and improved recovery of pressure development and coronary flow. Treatment with CS largely abrogates oxidative stress and damage in glucose‐ or pyruvate‐perfused hearts. Importantly, observed reductions in oxidative stress [glutathione disulfide (GSSG)]/[GSSG + glutathione] and [malondialdehyde (MDA)]/[superoxide dismutase + MDA] ratios as well as the resultant damage upon CS treatment correlate with functional markers of post‐ischemic myocardial outcome. These effects of CS were partially blocked by 8‐ρ‐sulfophenyltheophylline, an adenosine receptor antagonist. Our results demonstrate a suppressive role of CS in ischemic contracture. Meanwhile, the results also suggest pre‐ischemic adenosine receptor activation may be involved in reducing contracture in hearts pretreated with CS. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>Adenosine</subject><subject>adenosine receptor</subject><subject>Animals</subject><subject>antioxidant stress</subject><subject>Antioxidants - pharmacology</subject><subject>Cardiology</subject><subject>Cardiotonic Agents - pharmacology</subject><subject>Cordyceps - chemistry</subject><subject>Cordyceps sinensis</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Disulfide - metabolism</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>In Vitro Techniques</subject><subject>ischemia-reperfusion</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mycelium - chemistry</subject><subject>Myocardium - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Receptors, Purinergic P1 - metabolism</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Rodents</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Theophylline - analogs & derivatives</subject><subject>Theophylline - pharmacology</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10dFuFCEUBmBiNHatJj6BIfHGm6kwA8xwuW5q1VZda9XeEQbOROrssAJTd57CV5axa01MvAIOH38OOQg9puSIElI-36ZwxBop76AFJVIWlNfVXbQgktOC0ebyAD2I8YoQIkvC7qODsqKylFQs0M-VDtb5ax3N2OuA18EnMMn5AevB4uWQtztn9ZDwMpevXZqw73D6Cvh4l4I2KeIu-M3vytvJQO_0DFY-2HzaRvzRDTBEF-f3eK1DcrrvJ_w5u6WFwcd8j88h2-RDfIjudbqP8Gi_HqJPL48vVq-Ks_cnr1fLs8JUpJw_aAx0wCi3LYCpZSmEabggXdcKSq1tmS61bToDnAvD2hq4YJSxUgNQaapD9Owmdxv89xFiUhsXc_e9HsCPUWXKGl7XQmb69B965ccw5O5mVfGGVKz-G2iCjzFAp7bBbXSYFCVqHpLKQ1LzkDJ9sg8c2w3YW_hnKhkUN-CH62H6b5BaX5zvA_fexQS7W6_DNyXqqubqy7sTJS7r0xen_IN6U_0CR-StLg</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Yan, Xiao-Feng</creator><creator>Zhang, Zhong-Miao</creator><creator>Yao, Hong-Yi</creator><creator>Guan, Yan</creator><creator>Zhu, Jian-Ping</creator><creator>Zhang, Lin-Hui</creator><creator>Jia, Yong-Liang</creator><creator>Wang, Ru-Wei</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors</title><author>Yan, Xiao-Feng ; Zhang, Zhong-Miao ; Yao, Hong-Yi ; Guan, Yan ; Zhu, Jian-Ping ; Zhang, Lin-Hui ; Jia, Yong-Liang ; Wang, Ru-Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3029-15ccefe415dbeec79266c8560ffb611ddb4a2ad8fce556c4b7e5641442aee19c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenosine</topic><topic>adenosine receptor</topic><topic>Animals</topic><topic>antioxidant stress</topic><topic>Antioxidants - pharmacology</topic><topic>Cardiology</topic><topic>Cardiotonic Agents - pharmacology</topic><topic>Cordyceps - chemistry</topic><topic>Cordyceps sinensis</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Disulfide - metabolism</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>In Vitro Techniques</topic><topic>ischemia-reperfusion</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mycelium - chemistry</topic><topic>Myocardium - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Receptors, Purinergic P1 - metabolism</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Rodents</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Theophylline - analogs & derivatives</topic><topic>Theophylline - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Xiao-Feng</creatorcontrib><creatorcontrib>Zhang, Zhong-Miao</creatorcontrib><creatorcontrib>Yao, Hong-Yi</creatorcontrib><creatorcontrib>Guan, Yan</creatorcontrib><creatorcontrib>Zhu, Jian-Ping</creatorcontrib><creatorcontrib>Zhang, Lin-Hui</creatorcontrib><creatorcontrib>Jia, Yong-Liang</creatorcontrib><creatorcontrib>Wang, Ru-Wei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Xiao-Feng</au><au>Zhang, Zhong-Miao</au><au>Yao, Hong-Yi</au><au>Guan, Yan</au><au>Zhu, Jian-Ping</au><au>Zhang, Lin-Hui</au><au>Jia, Yong-Liang</au><au>Wang, Ru-Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2013-11</date><risdate>2013</risdate><volume>27</volume><issue>11</issue><spage>1597</spage><epage>1604</epage><pages>1597-1604</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>Mycelia of cultured Cordyceps sinensis (CS) is one of the most common substitutes for natural CS and was approved for arrhythmia in China. However, the role of CS in ameliorating injury during ischemia‐reperfusion (I/R) is still unclear. We examined effects of extracts from CS on I/R and investigated the possible mechanisms. Post‐ischemic coronary perfusion pressure, ventricular function, and coronary flow were measured using the Langendorff mouse heart model. Oxidative stress of cardiac homogenates was performed using an ELISA. Our results indicate that CS affords cardioprotection possibly through enhanced adenosine receptor activation. Cardioprotection was demonstrated by reduced post‐ischemic diastolic dysfunction and improved recovery of pressure development and coronary flow. Treatment with CS largely abrogates oxidative stress and damage in glucose‐ or pyruvate‐perfused hearts. Importantly, observed reductions in oxidative stress [glutathione disulfide (GSSG)]/[GSSG + glutathione] and [malondialdehyde (MDA)]/[superoxide dismutase + MDA] ratios as well as the resultant damage upon CS treatment correlate with functional markers of post‐ischemic myocardial outcome. These effects of CS were partially blocked by 8‐ρ‐sulfophenyltheophylline, an adenosine receptor antagonist. Our results demonstrate a suppressive role of CS in ischemic contracture. Meanwhile, the results also suggest pre‐ischemic adenosine receptor activation may be involved in reducing contracture in hearts pretreated with CS. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23192916</pmid><doi>10.1002/ptr.4899</doi><tpages>8</tpages></addata></record> |
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subjects | Adenosine adenosine receptor Animals antioxidant stress Antioxidants - pharmacology Cardiology Cardiotonic Agents - pharmacology Cordyceps - chemistry Cordyceps sinensis Glutathione - metabolism Glutathione Disulfide - metabolism Heart Heart - drug effects Heart - physiopathology In Vitro Techniques ischemia-reperfusion Male Malondialdehyde - metabolism Mice Mice, Inbred C57BL Mycelium - chemistry Myocardium - metabolism Oxidation-Reduction Oxidative stress Oxidative Stress - drug effects Receptors, Purinergic P1 - metabolism Reperfusion Injury - drug therapy Rodents Superoxide Dismutase - metabolism Theophylline - analogs & derivatives Theophylline - pharmacology |
title | Cardiovascular Protection and Antioxidant Activity of the Extracts from the Mycelia of Cordyceps Sinensis Act Partially Via Adenosine Receptors |
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