The many faces of solitary and multiple erythema migrans
Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema...
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| Veröffentlicht in: | Acta dermato-venereologica 2013-01, Vol.93 (6), p.693-700 |
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| container_title | Acta dermato-venereologica |
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| creator | Eriksson, Pernilla Schröder, Marika T Niiranen, Kirsi Nevanlinna, Antti Panelius, Jaana Ranki, Annamari |
| description | Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple erythema migrans lesions (usually 2 or 3) was almost equal (46%) to the proportion of patients with single erythema migrans lesions (54%). All patients, except for 2 multiple erythema migrans patients with a concomitant autoimmune disease, completely responded to treatment. In conclusion, multiple erythema migrans may be more common than anticipated, and since only 50% of the patients were seropositive when seeking medi-cal help, PCR testing of skin lesions is helpful to confirm the diagnosis in clinically atypical cases. |
| doi_str_mv | 10.2340/00015555-1549 |
| format | Article |
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However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple erythema migrans lesions (usually 2 or 3) was almost equal (46%) to the proportion of patients with single erythema migrans lesions (54%). All patients, except for 2 multiple erythema migrans patients with a concomitant autoimmune disease, completely responded to treatment. 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However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple erythema migrans lesions (usually 2 or 3) was almost equal (46%) to the proportion of patients with single erythema migrans lesions (54%). All patients, except for 2 multiple erythema migrans patients with a concomitant autoimmune disease, completely responded to treatment. In conclusion, multiple erythema migrans may be more common than anticipated, and since only 50% of the patients were seropositive when seeking medi-cal help, PCR testing of skin lesions is helpful to confirm the diagnosis in clinically atypical cases.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibodies, Bacterial - blood</subject><subject>Biopsy</subject><subject>Borrelia burgdorferi - genetics</subject><subject>Borrelia burgdorferi - immunology</subject><subject>Borrelia burgdorferi - isolation & purification</subject><subject>DNA, Bacterial - isolation & purification</subject><subject>Erythema Chronicum Migrans - diagnosis</subject><subject>Erythema Chronicum Migrans - drug therapy</subject><subject>Erythema Chronicum Migrans - microbiology</subject><subject>Erythema Chronicum Migrans - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Predictive Value of Tests</subject><subject>Retrospective Studies</subject><subject>Serologic Tests</subject><subject>Skin - drug effects</subject><subject>Skin - microbiology</subject><subject>Skin - pathology</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhiMEYmNw5Ipy5BKI6yRtj2jiS5rEZZyjtHVZUdOOpD3s39NqDF8s631syQ9jtyAfElTyUUoJeioBWuVnbAlGg0ikTs_Zcs7EHC7YVYzf05hoyC7ZYtrUEiUuWbbdEfeuO_DalRR5X_PYt83gwoG7ruJ-bIdm3xKncBh25B33zVdwXbxmF7VrI9389RX7fHnert_E5uP1ff20ESViMgjjcoWAVCAaY0DluSGtS0nGVaDr1IF2kBWUk4QcqwRNkUoo80q6OgNMcMXuj3f3of8ZKQ7WN7GktnUd9WO0oJTKtMlSOaHiiJahjzFQbfeh8dMnFqSdZdmTLDvLmvi7v9Nj4an6p0928BeUfmHS</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Eriksson, Pernilla</creator><creator>Schröder, Marika T</creator><creator>Niiranen, Kirsi</creator><creator>Nevanlinna, Antti</creator><creator>Panelius, Jaana</creator><creator>Ranki, Annamari</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>The many faces of solitary and multiple erythema migrans</title><author>Eriksson, Pernilla ; Schröder, Marika T ; Niiranen, Kirsi ; Nevanlinna, Antti ; Panelius, Jaana ; Ranki, Annamari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-6a94313eb3366614996e55c0e6ad15f7a15a18be9e0193d236b701c9d0af81323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibodies, Bacterial - blood</topic><topic>Biopsy</topic><topic>Borrelia burgdorferi - genetics</topic><topic>Borrelia burgdorferi - immunology</topic><topic>Borrelia burgdorferi - isolation & purification</topic><topic>DNA, Bacterial - isolation & purification</topic><topic>Erythema Chronicum Migrans - diagnosis</topic><topic>Erythema Chronicum Migrans - drug therapy</topic><topic>Erythema Chronicum Migrans - microbiology</topic><topic>Erythema Chronicum Migrans - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Predictive Value of Tests</topic><topic>Retrospective Studies</topic><topic>Serologic Tests</topic><topic>Skin - drug effects</topic><topic>Skin - microbiology</topic><topic>Skin - pathology</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eriksson, Pernilla</creatorcontrib><creatorcontrib>Schröder, Marika T</creatorcontrib><creatorcontrib>Niiranen, Kirsi</creatorcontrib><creatorcontrib>Nevanlinna, Antti</creatorcontrib><creatorcontrib>Panelius, Jaana</creatorcontrib><creatorcontrib>Ranki, Annamari</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eriksson, Pernilla</au><au>Schröder, Marika T</au><au>Niiranen, Kirsi</au><au>Nevanlinna, Antti</au><au>Panelius, Jaana</au><au>Ranki, Annamari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The many faces of solitary and multiple erythema migrans</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>93</volume><issue>6</issue><spage>693</spage><epage>700</epage><pages>693-700</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><abstract>Case definitions for European Lyme disease have been published. However, multiple erythema migrans may pose a diagnostic challenge. Therefore, we retrospectively reviewed the clinical and serological findings and response to therapy in a cohort of consecutive 54 patients with PCR-confirmed erythema migrans, referred to a university dermatology clinic. The proportion of patients with multiple erythema migrans lesions (usually 2 or 3) was almost equal (46%) to the proportion of patients with single erythema migrans lesions (54%). All patients, except for 2 multiple erythema migrans patients with a concomitant autoimmune disease, completely responded to treatment. In conclusion, multiple erythema migrans may be more common than anticipated, and since only 50% of the patients were seropositive when seeking medi-cal help, PCR testing of skin lesions is helpful to confirm the diagnosis in clinically atypical cases.</abstract><cop>Sweden</cop><pmid>23450303</pmid><doi>10.2340/00015555-1549</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Antibodies, Bacterial - blood Biopsy Borrelia burgdorferi - genetics Borrelia burgdorferi - immunology Borrelia burgdorferi - isolation & purification DNA, Bacterial - isolation & purification Erythema Chronicum Migrans - diagnosis Erythema Chronicum Migrans - drug therapy Erythema Chronicum Migrans - microbiology Erythema Chronicum Migrans - pathology Female Humans Male Middle Aged Polymerase Chain Reaction Predictive Value of Tests Retrospective Studies Serologic Tests Skin - drug effects Skin - microbiology Skin - pathology Treatment Outcome Young Adult |
| title | The many faces of solitary and multiple erythema migrans |
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