Eupatolide Inhibits PDGF-induced Proliferation and Migration of Aortic Smooth Muscle Cells Through ROS-dependent Heme Oxygenase-1 Induction

The abnormal proliferation and migration of vascular smooth muscle cell (VSMC) contributes importantly to the pathogenesis of atherosclerosis and restenosis. Here, we investigated the effects of eupatolide (EuTL), a sesquiterpene lactone isolated from the medicinal plant Inula britannica, on platele...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytotherapy research 2013-11, Vol.27 (11), p.1700-1707
Hauptverfasser:	Kim, Namho, Hwangbo, Cheol, Lee, Suhyun, Lee, Jeong-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Anthracenes - pharmacology Aorta - cytology Butadienes - pharmacology Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Chromones - pharmacology Enzyme Inhibitors - pharmacology eupatolide Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism heme oxygenase-1 Imidazoles - pharmacology Inula - chemistry Male migration Morpholines - pharmacology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism NF-E2-Related Factor 2 - metabolism Nitriles - pharmacology Platelet-Derived Growth Factor - pharmacology proliferation Pyridines - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Sesquiterpenes - pharmacology vascular smooth muscle cell
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!