CD1d-lipid antigen recognition by the γδ TCR

How γδ TCRs bind antigen presented by antigen-presenting molecules remains unclear. Godfrey and colleagues describe a population of human γδ T cells that interacts with CD1d and provide a molecular basis for how a γδ TCR binds CD1d–α-GalCer. The T cell repertoire comprises αβ and γδ T cell lineages....

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Veröffentlicht in:	Nature immunology 2013-11, Vol.14 (11), p.1137-1145
Hauptverfasser:	Uldrich, Adam P, Le Nours, Jérôme, Pellicci, Daniel G, Gherardin, Nicholas A, McPherson, Kirsty G, Lim, Ricky T, Patel, Onisha, Beddoe, Travis, Gras, Stephanie, Rossjohn, Jamie, Godfrey, Dale I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/2509 Amino Acid Sequence Antigen receptors, T cell Antigens, CD1d - chemistry Antigens, CD1d - immunology Autoimmunity Binding Sites Biomedicine Databases, Protein Galactosylceramides - chemistry Galactosylceramides - immunology Humans Immunology Infectious Diseases Molecular Docking Simulation Molecular Sequence Data Physiological aspects Protein Binding Protein Structure, Tertiary Receptors Receptors, Antigen, T-Cell, gamma-delta - chemistry Receptors, Antigen, T-Cell, gamma-delta - immunology Risk factors T cells T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology
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