Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age
In this study, we evaluated whether maternal obesity (MO) affects testis development and gonocyte differentiation in the rat from 0.5 to 14.5 postnatal days. Male Wistar rats were used at 0.5, 4.5, 7.5, and 14.5 days post partum (dpp). These rats were born from obese mothers, previously fed with a h...
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Veröffentlicht in: | Reproduction (Cambridge, England) England), 2013-12, Vol.146 (6), p.549-558 |
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description | In this study, we evaluated whether maternal obesity (MO) affects testis development and gonocyte differentiation in the rat from 0.5 to 14.5 postnatal days. Male Wistar rats were used at 0.5, 4.5, 7.5, and 14.5 days post partum (dpp). These rats were born from obese mothers, previously fed with a high-fat diet (20% saturated fat), for 15 weeks, or normal mothers that had received a balanced murine diet (4% lipids). MO did not affect testis weight or histology at birth but changed the migratory behavior of gonocytes. The density of relocated cells was higher in MO pups at 0.5 dpp, decreased at 4.5 dpp, and differed from those of control pups, where density increased exponentially from 0.5 to 7.5 dpp. The numerical density of gonocytes within seminiferous cords did not vary in MO, in relation to control neonates, for any age considered, but the testis weight was 50% lower at 4.5 dpp. A wide variation in plasmatic testosterone and estrogen levels was observed among the groups during the first week of age and MO pups exhibited higher steroid concentrations at 4.5 dpp, in comparison with controls. At this age, higher estrogen levels of MO pups impaired the gonocyte proliferation. At 7.5 dpp, the testicular size and other parameters of gonocyte development are retrieved. In conclusion, MO and saturated lipid diets disturb gonocyte development and sexual steroid levels during the first days of life, with recovery at prepubertal age. |
doi_str_mv | 10.1530/REP-13-0037 |
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Male Wistar rats were used at 0.5, 4.5, 7.5, and 14.5 days post partum (dpp). These rats were born from obese mothers, previously fed with a high-fat diet (20% saturated fat), for 15 weeks, or normal mothers that had received a balanced murine diet (4% lipids). MO did not affect testis weight or histology at birth but changed the migratory behavior of gonocytes. The density of relocated cells was higher in MO pups at 0.5 dpp, decreased at 4.5 dpp, and differed from those of control pups, where density increased exponentially from 0.5 to 7.5 dpp. The numerical density of gonocytes within seminiferous cords did not vary in MO, in relation to control neonates, for any age considered, but the testis weight was 50% lower at 4.5 dpp. A wide variation in plasmatic testosterone and estrogen levels was observed among the groups during the first week of age and MO pups exhibited higher steroid concentrations at 4.5 dpp, in comparison with controls. At this age, higher estrogen levels of MO pups impaired the gonocyte proliferation. At 7.5 dpp, the testicular size and other parameters of gonocyte development are retrieved. In conclusion, MO and saturated lipid diets disturb gonocyte development and sexual steroid levels during the first days of life, with recovery at prepubertal age.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-13-0037</identifier><identifier>PMID: 24043845</identifier><language>eng</language><publisher>England: BioScientifica</publisher><subject>Animals ; Animals, Newborn - growth & development ; Cell Differentiation ; Diet, High-Fat - adverse effects ; Female ; Germ Cells - drug effects ; Germ Cells - physiology ; Male ; Mothers ; Obesity ; Pregnancy ; Pregnancy Complications ; Prenatal Exposure Delayed Effects - physiopathology ; Rats ; Rats, Wistar ; Sexual Maturation - drug effects ; Sexual Maturation - physiology ; Testis - drug effects ; Testis - growth & development ; Testis - ultrastructure</subject><ispartof>Reproduction (Cambridge, England), 2013-12, Vol.146 (6), p.549-558</ispartof><rights>2013 Society for Reproduction and Fertility</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b410t-c8ff440df3da868ea0c75b030c034265167327fbf7df31213bdae554990361743</citedby><cites>FETCH-LOGICAL-b410t-c8ff440df3da868ea0c75b030c034265167327fbf7df31213bdae554990361743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24043845$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christante, Caroline Maria</creatorcontrib><creatorcontrib>Taboga, Sebastião Roberto</creatorcontrib><creatorcontrib>Pinto-Fochi, Maria Etelvina</creatorcontrib><creatorcontrib>Góes, Rejane Maira</creatorcontrib><title>Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>In this study, we evaluated whether maternal obesity (MO) affects testis development and gonocyte differentiation in the rat from 0.5 to 14.5 postnatal days. Male Wistar rats were used at 0.5, 4.5, 7.5, and 14.5 days post partum (dpp). These rats were born from obese mothers, previously fed with a high-fat diet (20% saturated fat), for 15 weeks, or normal mothers that had received a balanced murine diet (4% lipids). MO did not affect testis weight or histology at birth but changed the migratory behavior of gonocytes. The density of relocated cells was higher in MO pups at 0.5 dpp, decreased at 4.5 dpp, and differed from those of control pups, where density increased exponentially from 0.5 to 7.5 dpp. The numerical density of gonocytes within seminiferous cords did not vary in MO, in relation to control neonates, for any age considered, but the testis weight was 50% lower at 4.5 dpp. A wide variation in plasmatic testosterone and estrogen levels was observed among the groups during the first week of age and MO pups exhibited higher steroid concentrations at 4.5 dpp, in comparison with controls. At this age, higher estrogen levels of MO pups impaired the gonocyte proliferation. At 7.5 dpp, the testicular size and other parameters of gonocyte development are retrieved. In conclusion, MO and saturated lipid diets disturb gonocyte development and sexual steroid levels during the first days of life, with recovery at prepubertal age.</description><subject>Animals</subject><subject>Animals, Newborn - growth & development</subject><subject>Cell Differentiation</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Female</subject><subject>Germ Cells - drug effects</subject><subject>Germ Cells - physiology</subject><subject>Male</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sexual Maturation - drug effects</subject><subject>Sexual Maturation - physiology</subject><subject>Testis - drug effects</subject><subject>Testis - growth & development</subject><subject>Testis - ultrastructure</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKxDAYhuEgiueVe8lSkGrSpE27FBkPoCii65Kkf2YibVOTVJkL8L7NOOrSVQJ5-AgvQkeUnNGCkfOn2WNGWUYIExtolwpOM1HV9Wa6c0EyWublDtoL4ZUQWlSi3EY7OSecVbzYRZ_3MoIfZIedgmDjErc2xMmrgOMC8OhCHGRMzy28Q-fGHoaIncFzNzi9jBCwHb6llxF_2LhwU8S2H6X1vzShaAMO0U86LQNOcvQwTgr8alnO4QBtGdkFOPw599HL1ez58ia7e7i-vby4yxSnJGa6MoZz0hrWyqqsQBItCkUY0YTxvCxoKVgujDIiEZpTploJRcHrmrAyhWH76GS9O3r3NqV_Nb0NGrpODuCm0FDOOatZmkr0dE21dyF4MM3obS_9sqGkWXVvUveGsmbVPenjn-FJ9dD-2d_QCdA1UNYFbVMaa6yW_45-AZlTkIo</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Christante, Caroline Maria</creator><creator>Taboga, Sebastião Roberto</creator><creator>Pinto-Fochi, Maria Etelvina</creator><creator>Góes, Rejane Maira</creator><general>BioScientifica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age</title><author>Christante, Caroline Maria ; Taboga, Sebastião Roberto ; Pinto-Fochi, Maria Etelvina ; Góes, Rejane Maira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b410t-c8ff440df3da868ea0c75b030c034265167327fbf7df31213bdae554990361743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Animals, Newborn - growth & development</topic><topic>Cell Differentiation</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Female</topic><topic>Germ Cells - drug effects</topic><topic>Germ Cells - physiology</topic><topic>Male</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sexual Maturation - drug effects</topic><topic>Sexual Maturation - physiology</topic><topic>Testis - drug effects</topic><topic>Testis - growth & development</topic><topic>Testis - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christante, Caroline Maria</creatorcontrib><creatorcontrib>Taboga, Sebastião Roberto</creatorcontrib><creatorcontrib>Pinto-Fochi, Maria Etelvina</creatorcontrib><creatorcontrib>Góes, Rejane Maira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christante, Caroline Maria</au><au>Taboga, Sebastião Roberto</au><au>Pinto-Fochi, Maria Etelvina</au><au>Góes, Rejane Maira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2013-12</date><risdate>2013</risdate><volume>146</volume><issue>6</issue><spage>549</spage><epage>558</epage><pages>549-558</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>In this study, we evaluated whether maternal obesity (MO) affects testis development and gonocyte differentiation in the rat from 0.5 to 14.5 postnatal days. Male Wistar rats were used at 0.5, 4.5, 7.5, and 14.5 days post partum (dpp). These rats were born from obese mothers, previously fed with a high-fat diet (20% saturated fat), for 15 weeks, or normal mothers that had received a balanced murine diet (4% lipids). MO did not affect testis weight or histology at birth but changed the migratory behavior of gonocytes. The density of relocated cells was higher in MO pups at 0.5 dpp, decreased at 4.5 dpp, and differed from those of control pups, where density increased exponentially from 0.5 to 7.5 dpp. The numerical density of gonocytes within seminiferous cords did not vary in MO, in relation to control neonates, for any age considered, but the testis weight was 50% lower at 4.5 dpp. A wide variation in plasmatic testosterone and estrogen levels was observed among the groups during the first week of age and MO pups exhibited higher steroid concentrations at 4.5 dpp, in comparison with controls. At this age, higher estrogen levels of MO pups impaired the gonocyte proliferation. At 7.5 dpp, the testicular size and other parameters of gonocyte development are retrieved. In conclusion, MO and saturated lipid diets disturb gonocyte development and sexual steroid levels during the first days of life, with recovery at prepubertal age.</abstract><cop>England</cop><pub>BioScientifica</pub><pmid>24043845</pmid><doi>10.1530/REP-13-0037</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Animals, Newborn - growth & development Cell Differentiation Diet, High-Fat - adverse effects Female Germ Cells - drug effects Germ Cells - physiology Male Mothers Obesity Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects - physiopathology Rats Rats, Wistar Sexual Maturation - drug effects Sexual Maturation - physiology Testis - drug effects Testis - growth & development Testis - ultrastructure |
title | Maternal obesity disturbs the postnatal development of gonocytes in the rat without impairment of testis structure at prepubertal age |
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